116507-04-1|L 658758|((6R,7S)-3-(acetoxymethyl)-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyl)-L-proline|-范德生物科技公司

L 658758

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names：
((6R,7S)-3-(acetoxymethyl)-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyl)-L-proline
CAS号：
116507-04-1
MDL Number：
MF(分子式)： C16H20N2O9S MW(分子量)： 416.4
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L 658758
英文别名	L 658758; L-658758; L658758; L-658,758; L 658,758; L658,758;
CAS号	116507-04-1
Inchi	InChI=1S/C16H20N2O9S/c1-8(19)27-6-9-7-28(24,25)15-12(26-2)14(21)18(15)11(9)13(20)17-5-3-4-10(17)16(22)23/h10,12,15H,3-7H2,1-2H3,(H,22,23)/t10-,12-,15+/m0/s1
InchiKey	SMZXYXKZTNLAKY-ITDIGPHOSA-N
分子式 Formula	C16H20N2O9S
分子量 Molecular Weight	416.4
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 658758(CAS:116507-04-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 658758 is a Serine Proteinase Inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kawai M, Harada N, Takeyama H, Okajima K. Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats. Transl Res. 2010 Jun;155(6):294-304. doi: 10.1016/j.trsl.2010.02.003. Epub 2010 Mar 19. PubMed PMID: 20478544.

[2]Harada N, Okajima K, Isobe H. Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats. Shock. 2008 Oct;30(4):379-87. doi: 10.1097/SHK.0b013e3181673e2c. Erratum in: Shock. 2012 Oct;38(4):446. PubMed PMID: 18323746.

[3] Okajima K, Harada N, Uchiba M, Mori M. Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1116-23. Epub 2004 Jul 8. PubMed PMID: 15246960.

[4] Liu W, Okajima K, Murakami K, Harada N, Isobe H, Irie T. Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. J Lab Clin Med. 1998 Nov;132(5):432-9. PubMed PMID: 9823937.

[5] Carden D, Xiao F, Moak C, Willis BH, Robinson-Jackson S, Alexander S. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998 Aug;275(2 Pt 2):H385-92. PubMed PMID: 9683424.

6: Taoka Y, Okajima K, Murakami K, Johno M, Naruo M. Role of neutrophil elastase in compression-induced spinal cord injury in rats. Brain Res. 1998 Jul 20;799(2):264-9. Erratum in: Brain Res. 2011 Aug 23;1408:98. PubMed PMID: 9675307.7: Rees DD, Brain JD, Wohl ME, Humes JL, Mumford RA. Inhibition of neutrophil elastase in CF sputum by L-658,758. J Pharmacol Exp Ther. 1997 Dec;283(3):1201-6. PubMed PMID: 9399994.8: Murakami K, Okajima K, Uchiba M, Harada N, Liu W, Okabe H, Takatsuki K. Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats. J Lab Clin Med. 1997 Sep;130(3):307-13. PubMed PMID: 9341991.9: Carden DL, Korthuis RJ. Protease inhibition attenuates microvascular dysfunction in postischemic skeletal muscle. Am J Physiol. 1996 Nov;271(5 Pt 2):H1947-52. PubMed PMID: 8945913.10: Fletcher DS, Osinga DG, Keenan K, Bonney RJ, Doherty JB, Finke PE, Shah SK, Davies P. An inhibitor of leukocyte elastase prevents immune complex-mediated hemorrhage in the rat lung. J Pharmacol Exp Ther. 1995 Jul;274(1):548-54. PubMed PMID: 7616444.1

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