214764-26-8|KW-7158|(S)-N-(5,5-dioxido-10-oxo-4,10-dihydrobenzo[b]thieno[2,3-e]thiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide|-范德生物科技公司

KW-7158

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names：
(S)-N-(5,5-dioxido-10-oxo-4,10-dihydrobenzo[b]thieno[2,3-e]thiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
CAS号：
214764-26-8
MDL Number：
MF(分子式)： C16H12F3NO5S2 MW(分子量)： 419.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KW-7158
英文别名	KW-7158; KW7158; KW 7158
CAS号	214764-26-8
Inchi	InChI=1S/C16H12F3NO5S2/c1-15(23,16(17,18)19)14(22)20-9-3-2-4-10-11(9)12(21)13-8(5-6-26-13)7-27(10,24)25/h2-6,23H,7H2,1H3,(H,20,22)/t15-/m0/s1
InchiKey	NAFSYPCVPLWHFY-HNNXBMFYSA-N
分子式 Formula	C16H12F3NO5S2
分子量 Molecular Weight	419.38
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KW-7158(CAS:214764-26-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KW-7158 is a potassium channel activator potentially for the treatment of urinary urgency and frequency
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Nishiya Y, Yamagata T, Fukuda A, Yokokawa S, Seishi T, Sakuma T, Sasho S, Shimizu Y, Sato H, Sekine S, Kamigaki M, Yoshida T, Shibata K. The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-[1]Biol Pharm Bull. 2014;37(1):130-6. PubMed PMID: 24162843.

[2]Maeda H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: a pharmacokinetic study in male and female rats. Arzneimittelforschung. 2012 May;62(5):213-21. doi: 10.1055/s-0032-1301883. PubMed PMID: 22344572.

[3] Maeda H, Kodaira H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[ 3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals. Xenobiotica. 2012 Jul;42(7):649-59. doi: 10.3109/00498254.2011.652993. PubMed PMID: 22324379.

[4] Nishiya Y, Yokokawa S, Fukuda A, Yamagata T, Inayoshi A, Obinata M, Shibata K. The generation of rat dorsal root ganglion cell lines to identify the target of KW-7158, a novel treatment for overactive bladder. Neurosci Res. 2011 Nov;71(3):278-88. doi: 10.1016/j.neures.2011.07.1823. PubMed PMID: 21802454.

[5] Sculptoreanu A, Yoshimura N, de Groat WC. KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[ 3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat. J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. PubMed PMID: 15010502.

6: Lu SH, Yamagata T, Atsuki K, Sun L, Smith CP, Yoshimura N, Chancellor MB, de Groat WC. Effect of KW-7158, a putative afferent nerve inhibitor, on bladder and vesico-vascular reflexes in rats. Brain Res. 2002 Aug 9;946(1):72-8. PubMed PMID: 12133596.

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