126643-38-7|KT5926|methyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-11-propoxy-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylate|-范德生物科技公司

KT5926

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names：
methyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-11-propoxy-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylate
CAS号：
126643-38-7
MDL Number：
MF(分子式)： C30H27N3O6 MW(分子量)： 525.561
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KT5926
英文别名	KT5926; KT-5926; KT 5926.
CAS号	126643-38-7
SMILES	O=C([C@]1(O)[C@@](O2)(C)N3C4=CC=CC=C4C5=C3C6=C(C7=CC(OCCC)=CC=C7N6[C@@]2([H])C1)C8=C5CNC8=O)OC
Inchi	InChI=1S/C30H27N3O6/c1-4-11-38-15-9-10-19-17(12-15)23-24-18(14-31-27(24)34)22-16-7-5-6-8-20(16)33-26(22)25(23)32(19)21-13-30(36,28(35)37-3)29(33,2)39-21/h5-10,12,21,36H,4,11,13-14H2,1-3H3,(H,31,34)/t21-,29+,30+/m1/s1
InchiKey	ZZWAFVPZTZSAEM-RIGQTMPJSA-N
分子式 Formula	C30H27N3O6
分子量 Molecular Weight	525.561
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KT5926(CAS:126643-38-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KT5926 is a potent and selective inhibitor of myosin light chain kinase. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation. KT5926 is an analogue of K-252a, which blocks all responses to NGF, it does not affect other NGF-elicited cellular responses examined, including NGF-dependent priming of cells, gp140prototrk autophosphorylation, immediate-early gene induction, and phosphorylation of several known cytoskeletal proteins (MAP 1.2/1B, chartin MAPs, and beta-tubulin).
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kim YS, Kawai A. Studies on the antiviral mechanisms of protein kinase inhibitors K-252a and KT5926 against the replication of vesicular stomatitis virus. Biol Pharm Bull. 1998 May;21(5):498-505. PubMed PMID: 9635507.

[2]Oberstar JV, Challacombe JF, Roche FK, Letourneau PC. Concentration-dependent stimulation and inhibition of growth cone behavior and neurite elongation by protein kinase inhibitors KT5926 and K-252a. J Neurobiol. 1997 Aug;33(2):161-71. PubMed PMID: 9240372.

[3] Abraham I, Wolf CL, Sampson KE, Laborde AL, Shelly JA, Aristoff PA, Skulnick HI. K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel. Cancer Res. 1994 Nov 15;54(22):5889-94. PubMed PMID: 7954419.

[4] Teng KK, Greene LA. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation. J Neurosci. 1994 May;14(5 Pt 1):2624-35. PubMed PMID: 8182431.

[5] Hashimoto Y, Nakayama T, Teramoto T, Kato H, Watanabe T, Kinoshita M, Tsukamoto K, Tokunaga K, Kurokawa K, Nakanishi S, et al. Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926. Biochem Biophys Res Commun. 1991 Nov 27;181(1):423-9. PubMed PMID: 1659814.

6: Nakanishi S, Yamada K, Iwahashi K, Kuroda K, Kase H. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol Pharmacol. 1990 Apr;37(4):482-8. PubMed PMID: 2325635.

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