137005-17-5|Ksg 504|L-Arginine, mono((R)-5-((3-methoxypropyl)pentylamino)-4-((2-naphthalenylsulfonyl)methyl)-5-oxopentanoate)|-范德生物科技公司

Ksg 504

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names：
L-Arginine, mono((R)-5-((3-methoxypropyl)pentylamino)-4-((2-naphthalenylsulfonyl)methyl)-5-oxopentanoate)
CAS号：
137005-17-5
MDL Number：
MF(分子式)： C31H49N5O8S MW(分子量)： 651.82
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Ksg 504
英文别名	Ksg 504; Ksg504; Ksg-504
CAS号	137005-17-5
Inchi	InChI=1S/C25H35NO6S.C6H14N4O2/c1-3-4-7-15-26(16-8-17-32-2)25(29)22(12-14-24(27)28)19-33(30,31)23-13-11-20-9-5-6-10-21(20)18-23;7-4(5(11)12)2-1-3-10-6(8)9/h5-6,9-11,13,18,22H,3-4,7-8,12,14-17,19H2,1-2H3,(H,27,28);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t22-;4-/m00/s1
InchiKey	TXTJVOOURRNANH-QEXBQMGZSA-N
分子式 Formula	C31H49N5O8S
分子量 Molecular Weight	651.82
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ksg 504(CAS:137005-17-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ksg 504 has superior selectivity and affinity to CCK-A receptors and derived from proglumide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Okumura Y, Inoue H, Fujiyama Y, Bamba T. Effects of short-term administration of the CCK receptor antagonist, KSG-504, on regeneration of pancreatic acinar cells in acute pancreatitis in rats. J Gastroenterol. 1995 Aug;30(4):493-9. PubMed PMID: 7550860.

[2]Takács T, Czakó L, Jármay K, Farkas G Jr, Mándi Y, Lonovics J. Cytokine level changes in L-arginine-induced acute pancreatitis in rat. Acta Physiol Hung. 1996;84(2):147-56. PubMed PMID: 9046361.

[3] Moriyoshi Y, Shiratori K, Takeuchi T, Watanabe S. A new CCK-A antagonist, KSG-504, administered intraduodenally, inhibits pancreatic secretion in rats. Pancreas. 1994 Mar;9(2):225-9. PubMed PMID: 8190724.

[4] Yamazaki Y, Takeda H, Akahane M, Tsubaki A, Ajisawa Y. [Behavioral studies of KSG-504, a new CCK-A receptor antagonist]. Nihon Yakurigaku Zasshi. 1996 Jan;107(1):21-31. Japanese. PubMed PMID: 8720295.

[5] Ha S, Satake K, Hiura A, Sowa M, Nishiwaki H. Effect of a new cholecystokinin receptor antagonist (KSG 504) on the early stage of the healing process in acute pancreatitis induced in rats by the closed duodenal loop technique. Pancreas. 1994 Jul;9(4):501-7. PubMed PMID: 7524065.

6: Yamazaki Y, Akahane M, Kobayashi M, Shinagawa K, Sugiura M, Ajisawa Y. [Effects of KSG-504, a new CCK-A receptor antagonist, on gallbladder and gastrointestinal functions]. Nihon Yakurigaku Zasshi. 1996 Jan;107(1):33-44. Japanese. PubMed PMID: 8720296.7: Kihara Y, Otsuki M. Different inhibitory effects of the newly developed CCK receptor antagonists FK480 and KSG-504 on pancreatic exocrine and endocrine secretion in the isolated perfused rat pancreas. Pancreas. 1995 Mar;10(2):109-17. PubMed PMID: 7716133.8: Yamazaki Y, Akahane M, Kobayashi M, Kitazawa M, Kurashina Y, Iizuka K. Pharmacological profile of KSG-504, a new cholecystokinin-A-receptor antagonist. Jpn J Pharmacol. 1993 Oct;63(2):219-25. PubMed PMID: 7506805.9: Okumura Y, Bamba T, Shintani Y, Yoshioka U, Inoue H, Fujiyama Y, Hosoda S. [Effect of KSG-504, a new synthetic cholecystokinin receptor antagonist on ethionine-induced acute pancreatitis in rats]. Nihon Shokakibyo Gakkai Zasshi. 1993 Dec;90(12):3032-40. Japanese. PubMed PMID: 8283814.10: Yamazaki Y, Shinagawa K, Takeda H, Kobayashi M, Akahane M, Ajisawa Y. Cholecystokinin-A specific antagonism of KSG-504 to cholecystokinin receptor binding and pancreatic secretion in mammals. Jpn J Pharmacol. 1995 Dec;69(4):367-73. PubMed PMID: 8786640.1

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