335381-68-5|KR-31378|Guanidine, N-((2S,3S,4R)-6-amino-2-(dimethoxymethyl)-3,4-dihydro-3-hydroxy-2-methyl-2H-1-benzopyran-4-yl)-N'-cyano-N''-(phenylmethyl)-|-范德生物科技公司

KR-31378

NMR下载 COA and HPLC MSDS下载
names：
Guanidine, N-((2S,3S,4R)-6-amino-2-(dimethoxymethyl)-3,4-dihydro-3-hydroxy-2-methyl-2H-1-benzopyran-4-yl)-N'-cyano-N''-(phenylmethyl)-
CAS号：
335381-68-5
MDL Number：
MF(分子式)： C22H27N5O4 MW(分子量)： 425.48
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	KR-31378
英文别名	DNB-001; KR-31378; MSH-1001; DNB001; KR31378; MSH1001; DNB 001; KR 31378; MSH 1001
CAS号	335381-68-5
Inchi	InChI=1S/C22H27N5O4/c1-22(20(29-2)30-3)19(28)18(16-11-15(24)9-10-17(16)31-22)27-21(26-13-23)25-12-14-7-5-4-6-8-14/h4-11,18-20,28H,12,24H2,1-3H3,(H2,25,26,27)/t18-,19+,22+/m1/s1
InchiKey	OZHUPJHJQIEDFA-DXIQSLLYSA-N
分子式 Formula	C22H27N5O4
分子量 Molecular Weight	425.48
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KR-31378(CAS:335381-68-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KR-31378, also known as DNB-001 and MSH-1001, is a K(ATP) channel activator potentially for the treatment of ocular hypertension and glaucoma
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Choi A, Choi JS, Yoon YJ, Kim KA, Joo CK. KR-31378, a potassium-channel opener, induces the protection of retinal ganglion cells in rat retinal ischemic models. J Pharmacol Sci. 2009 Apr;109(4):511-7. PubMed PMID: 19372634.

[2]Hwang GS, Oh KS, Koo HN, Seo HW, You KH, Lee BH. Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure. Eur J Pharmacol. 2006 Jul 1;540(1-3):131-8. PubMed PMID: 16729997.

[3] Lee CH, Choi KY, Kim YJ, Kim WG. Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits. J Invest Surg. 2005 Nov-Dec;18(6):297-304. PubMed PMID: 16319050.

[4] Kim MY, Lee S, Yi KY, Yoo SE, Lee DH, Lim H, Kim HS, Lee SH, Baik EJ, Moon CH, Jung YS. Protective effect of KR-31378 on oxidative stress in cardiac myocytes. Arch Pharm Res. 2005 Dec;28(12):1358-64. PubMed PMID: 16392669.

[5] Moon CH, Kim MY, Kim MJ, Kim MH, Lee S, Yi KY, Yoo SE, Lee DH, Lim H, Kim HS, Lee SH, Baik EJ, Jung YS. KR-31378, a novel benzopyran analog, attenuates hypoxia-induced cell death via mitochondrial KATP channel and protein kinase C-epsilon in heart-derived H9c2 cells. Eur J Pharmacol. 2004 Dec 3;506(1):27-35. PubMed PMID: 15588621.

6: Kim KY, Lee JH, Park JH, Yoo MA, Kwak YG, Kim SO, Yoo SE, Hong KW. Anti-apoptotic action of (2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2 H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378) by suppression of the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and increased phosphorylation of casein kinase2/Akt/ cyclic AMP response element binding protein via maxi-K channel opening in neuronal cells. Eur J Pharmacol. 2004 Aug 30;497(3):267-77. PubMed PMID: 15336944.7: Won R, Lim JY, Lee SY, Park JH, Sohn NW. Neuroprotective effect of KR-31378 via KATP channel opening against ischemic insult. Biol Pharm Bull. 2004 Aug;27(8):1285-8. PubMed PMID: 15305038.8: Jung YS, Lee DH, Lim H, Yi KY, Yoo SE, Kim E. KR-31378 protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation. Jpn J Physiol. 2004 Dec;54(6):575-83. PubMed PMID: 15760490.9: Kim SO, Cho IS, Gu HK, Lee DH, Lim H, Yoo SE. KR-31378 protects neurons from ischemia-reperfusion brain injury by attenuating lipid peroxidation and glutathione loss. Eur J Pharmacol. 2004 Mar 8;487(1-3):81-91. PubMed PMID: 15033379.10: Kim SO, Kwak SH, Lee BH, Lee DH, Lim H, Yoo SE, Chung HJ, Lee MG. Dose-dependent pharmacokinetics of KR-31378, a new neuroprotective agent for ischaemia-reperfusion damage in dogs. Biopharm Drug Dispos. 2004 Apr;25(3):143-8. PubMed PMID: 15083503.1

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