421556-16-3|KMUP-3|1,3-dimethyl-7-(2-(4-(4-nitrophenyl)piperazin-1-yl)ethyl)-3,7-dihydro-1H-purine-2,6-dione|-范德生物科技公司

KMUP-3

NMR下载 COA and HPLC MSDS下载
names：
1,3-dimethyl-7-(2-(4-(4-nitrophenyl)piperazin-1-yl)ethyl)-3,7-dihydro-1H-purine-2,6-dione
CAS号：
421556-16-3
MDL Number：
MF(分子式)： C19H23N7O4 MW(分子量)： 413.43
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KMUP-3
英文别名	KMUP-3; KMUP 3; KMUP3;
CAS号	421556-16-3
SMILES	CN1C(N(C)C(N=CN2CCN3CCN(C4=CC=C([N+]([O-])=O)C=C4)CC3)=C2C1=O)=O
Inchi	InChI=1S/C19H23N7O4/c1-21-17-16(18(27)22(2)19(21)28)25(13-20-17)12-9-23-7-10-24(11-8-23)14-3-5-15(6-4-14)26(29)30/h3-6,13H,7-12H2,1-2H3
InchiKey	WUNWRZDRKZFAHV-UHFFFAOYSA-N
分子式 Formula	C19H23N7O4
分子量 Molecular Weight	413.43
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KMUP-3(CAS:421556-16-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KMUP-3 is an enhancer of cGMP activity. It also acts as an aortic smooth muscle relaxant.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Liu CP, Yeh JL, Liou SF, Wu BN, Chen IJ. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization. Kaohsiung J Med Sci. 2016 Feb;32(2):55-67. doi: 10.1016/j.kjms.2016.01.005. Epub 2016 Feb 24. PubMed PMID: 26944323.

[2]Winardi W, Wang CJ, Lin CL, Wu SC, Tsai HP, Kuo YH, Lee MY, Chen IJ, Kwan AL. Attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage by the bronchodilator KMUP-3. Acta Neurochir Suppl. 2013;11

5:239-46. doi: 10.1007/978-3-7091-1192-5_43. PubMed PMID: 22890675.

[4]Liu CP, Yeh JL, Wu BN, Chai CY, Chen IJ, Lai WT. KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance. Br J Pharmacol. 2011 Jan;162(1):126-35. doi: 10.1111/j.1476-5381.2010.01024.x. PubMed PMID: 20840538; PubMed Central PMCID: PMC3012411.

[5] Wu BN, Chen CW, Liou SF, Yeh JL, Chung HH, Chen IJ. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G. Mol Pharmacol. 2006 Sep;70(3):977-85. Epub 2006 Jun 5. PubMed PMID: 16754782.

5: Lin RJ, Wu BN, Lo YC, An LM, Dai ZK, Lin YT, Tang CS, Chen IJ. A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G. J Pharmacol Exp Ther. 2006 Feb;316(2):709-17. Epub 2005 Oct 18. PubMed PMID: 16234412.

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