11072-82-5|Kidamycin|(Z)-2-(but-2-en-2-yl)-10-(4-(dimethylamino)-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)-8-(4-(dimethylamino)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-11-hydroxy-5-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione|-范德生物科技公司

Kidamycin

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names：
(Z)-2-(but-2-en-2-yl)-10-(4-(dimethylamino)-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)-8-(4-(dimethylamino)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-11-hydroxy-5-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
CAS号：
11072-82-5
MDL Number：
MF(分子式)： C39H48N2O9 MW(分子量)： 688.82
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Kidamycin
英文别名	Kidamycin; Iyomycin-F;
CAS号	11072-82-5
Inchi	InChI=1S/C39H48N2O9/c1-11-17(2)26-15-25(42)29-18(3)12-23-31(37(29)50-26)36(46)32-30(35(23)45)21(27-14-24(40(7)8)33(43)19(4)48-27)13-22(34(32)44)28-16-39(6,41(9)10)38(47)20(5)49-28/h11-13,15,19-20,24,27-28,33,38,43-44,47H,14,16H2,1-10H3/b17-11-
InchiKey	MFTJRTUKCOVIMD-BOPFTXTBSA-N
分子式 Formula	C39H48N2O9
分子量 Molecular Weight	688.82
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Kidamycin(CAS:11072-82-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Kidamycin is obtained from Streptomyces phaeoverticillatus strains and interferes with RNA synthesis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Fei Z, McDonald FE. Stereo- and regioselective glycosylations to the bis-C-arylglycoside of kidamycin. Org Lett. 2007 Aug 30;9(18):3547-50. Epub 2007 Aug 1[1]PubMed PMID: 17691798; PubMed Central PMCID: PMC4604443.

[2]Fei Z, McDonald FE. Synthesis of the aglycones of altromycins and kidamycin from a common intermediate. Org Lett. 2005 Aug 18;7(17):3617-20. PubMed PMID: 16092833; PubMed Central PMCID: PMC1388187.

[3] Takeshima H, Okamoto M, Komiyama K, Umezawa I. Mechanism of action of acetyl kidamycin. I. Interaction with DNA. Biochim Biophys Acta. 1976 Jan 5;418(1):24-8. PubMed PMID: 942683.

[4] Umezawa I, Komiyama K, Takeshima H, Hata T, Kono M. A new antitumor antibiotic, kidamycin. IV. Pharmacokinetics of acetyl-kidamycin. J Antibiot (Tokyo). 1973 Nov;26(11):669-75. PubMed PMID: 4792114.

[5] Kanda N. A new antitumor antibiotic, kidamycin. I. Isolation, purification and properties of kidamycin. J Antibiot (Tokyo). 1971 Sep;24(9):599-606. PubMed PMID: 5132247.

6: Kanda N. A new antitumor antibiotic, kidamycin. 3. Preparation and properties of acetyl kidamycin. J Antibiot (Tokyo). 1972 Oct;25(10):557-60. PubMed PMID: 4648310.7: Kanda N, Kono M, Asano K. A new antitumor antibiotic, kidamycin. II. Experimental treatment of cancer with kidamycin. J Antibiot (Tokyo). 1972 Oct;25(10):553-6. PubMed PMID: 4648309.8: Fujita H, Sawabe T, Hanawa Y, Kimura K. [In vivo distribution of daunomycin, acetyl kidamycin, actinomycin D and chromomycin A3]. Gan No Rinsho. 1971 Mar;17(3):196-204. Japanese. PubMed PMID: 5102102.9: Okamoto M, Takeshima H, Komiyama K, Umezawa I. Mechanism of action of acetyl kidamycin. II. Inhibition of RNA synthesis in HeLa cells. J Antibiot (Tokyo). 1976 Dec;29(12):1334-8. PubMed PMID: 1010801.10: Kumazawa M, Inada S, Namiki M, Ishii S, Tago K. Mechanism of action of antitumor agents on bacteria. II. Effect of acetyl-kidamycin on nucleic acids. Kitasato Arch Exp Med. 1974 Sep;47(3):79-88. PubMed PMID: 4218625.1

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