171277-06-8|JTH-601 free base|3-(((2-(4-hydroxy-2-isopropyl-5-methylphenoxy)ethyl)(methyl)amino)methyl)-4-methoxy-2,5,6-trimethylphenol|-范德生物科技公司

JTH-601 free base

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names：
3-(((2-(4-hydroxy-2-isopropyl-5-methylphenoxy)ethyl)(methyl)amino)methyl)-4-methoxy-2,5,6-trimethylphenol
CAS号：
171277-06-8
MDL Number：
MF(分子式)： C24H35NO4 MW(分子量)： 401.54
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	JTH-601 free base
英文别名	JTH-601; JTH-601 free base;
CAS号	171277-06-8
Inchi	InChI=1S/C24H35NO4/c1-14(2)19-12-21(26)15(3)11-22(19)29-10-9-25(7)13-20-18(6)23(27)16(4)17(5)24(20)28-8/h11-12,14,26-27H,9-10,13H2,1-8H3
InchiKey	VXLRYJNESHCVDX-UHFFFAOYSA-N
分子式 Formula	C24H35NO4
分子量 Molecular Weight	401.54
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	JTH-601 free base(CAS:171277-06-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	JTH-601 free base is an alpha 1 adenergic recepor anagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nobata K, Fujimura M, Ishiura Y, Hirose T, Furusyou S, Myou S, Kurashima K, Kasahara K, Nakao S. Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. Eur J Pharmacol. 2002 Sep 27;452(1):97-104. PubMed PMID: 12323390.

[2]Hirai T, Tsuru H, Tanimitsu N, Yajin K, Sasa M. Effect of JTH-601, a putative alpha(1L)-adrenoceptor antagonist, on guinea pig nasal mucosa vasculature. Eur J Pharmacol. 2001 Mar 23;416(1-2):141-4. PubMed PMID: 11282123.

[3] Qiao X, Norota I, Endoh M. Pharmacological characteristics of inhibitory action of the selective alpha1-antagonist JTH-601 on the positive inotropic effect mediated by alpha1-adrenoceptors in isolated rabbit papillary muscle. Jpn J Pharmacol. 2000 Nov;84(3):301-9. PubMed PMID: 11138731.

[4] Yamada S, Okura T, Kimura R, Deguchi Y, Suzuki Y, Kobayashi T, Aisaka K. Disposition and alpha(1)-adrenoceptor binding characteristics of JTH-601 and its metabolites in rat tissues. Drug Metab Dispos. 2000 Dec;28(12):1487-92. PubMed PMID: 11095588.

[5] Takahashi M, Taniguchi T, Kanamaru H, Okada K, Muramatsu I. Pharmacological characterization of [3H]-JTH-601, a novel alpha1-adrenoceptor antagonist: binding to recombinant human alpha1-adrenoceptors and human prostates. Life Sci. 2000 Oct 6;67(20):2443-51. PubMed PMID: 11065167.

6: Suzuki Y, Moriyama N, Okaya Y, Kanada A, Nishimatsu H, Kawabe K, Aisaka K. Distribution of alpha1L-adrenoceptors in canine prostate: characterization by quantitative autoradiography. J Pharm Pharmacol. 2000 Jun;52(6):653-7. PubMed PMID: 10875541.7: Suzuki Y, Kanada A, Okaya Y, Aisaka K. Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30. PubMed PMID: 10771044.8: Suzuki Y, Kanada A, Okaya Y, Kurahashi Y, Kogayu M, Kobayashi T, Aisaka K. Prostate selectivity of JTH-601-G1, an active metabolite of JTH-601, in dogs. BJU Int. 2000 Mar;85(4):542-50. PubMed PMID: 10691841.9: Suzuki Y, Moriyama N, Kanada A, Okaya Y, Kawabe K, Aisaka K. The role of alpha 1L-adrenoceptor in rat urinary bladder: comparison between young adult and aged rats. Life Sci. 1999;65(24):2553-9. PubMed PMID: 10619363.10: Suzuki Y, Moriyama N, Okaya Y, Nishimatsu H, Kawabe K, Aisaka K. Age-related change of the role of alpha1L-adrenoceptor in canine urethral smooth muscle. Gen Pharmacol. 1999 Oct;33(4):347-54. PubMed PMID: 10523074.1

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