117550-12-6|Jom 13|(S)-2-((S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-mercaptopropanamido)-3-phenylpropanoic (S)-2-amino-3-mercapto-3-methylbutanoic anhydride|-范德生物科技公司

Jom 13

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names：
(S)-2-((S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-mercaptopropanamido)-3-phenylpropanoic (S)-2-amino-3-mercapto-3-methylbutanoic anhydride
CAS号：
117550-12-6
MDL Number：
MF(分子式)： C26H34N4O6S2 MW(分子量)： 562.7
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Jom 13
英文别名	Jom 13; H-Tyrosyl-cyclo(cysteinyl-phenylalanyl-penicillaminyl)-OH; DCFPE; Htdcpdp-OH;
CAS号	117550-12-6
Inchi	InChI=1S/C26H34N4O6S2/c1-26(2,38)21(28)25(35)36-24(34)19(13-15-6-4-3-5-7-15)29-23(33)20(14-37)30-22(32)18(27)12-16-8-10-17(31)11-9-16/h3-11,18-21,31,37-38H,12-14,27-28H2,1-2H3,(H,29,33)(H,30,32)/t18-,19-,20+,21-/m0/s1
InchiKey	LINHQEFGHROEAQ-BURNTYAHSA-N
分子式 Formula	C26H34N4O6S2
分子量 Molecular Weight	562.7
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Jom 13(CAS:117550-12-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Jom 13 is a cyclic delta receptor selective tetrapeptide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. Brain Res. 2006 Jan 19;1069(1):172-8[1]Epub 2005 Dec 20. PubMed PMID: 16364263; PubMed Central PMCID: PMC1780167.

[2]Mosberg HI, Fowler CB. Development and validation of opioid ligand-receptor interaction models: the structural basis of mu vs delta selectivity. J Pept Res. 2002 Dec;60(6):329-35. PubMed PMID: 12464111.

[3] Mosberg HI. Complementarity of delta opioid ligand pharmacophore and receptor models. Biopolymers. 1999;51(6):426-39. Review. PubMed PMID: 10797231.

[4] Mansour A, Taylor LP, Fine JL, Thompson RC, Hoversten MT, Mosberg HI, Watson SJ, Akil H. Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. J Neurochem. 1997 Jan;68(1):344-53. PubMed PMID: 8978745.

[5] Mosberg HI, Dua RK, Pogozheva ID, Lomize AL. Development of a model for the delta-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain. Biopolymers. 1996 Sep;39(3):287-96. PubMed PMID: 8756510.

6: Gao P. Comparison of cyclic delta-opioid peptides with non-peptide delta-agonist spiroindanyloxymorphone (SIOM) using the message-address concept: a molecular modeling study. J Comput Aided Mol Des. 1996 Aug;10(4):327-36. PubMed PMID: 8877704.7: Brandt W, Stoldt M, Schinke H. The mu- and delta-opioid pharmacophore conformations of cyclic beta-casomorphin analogues indicate docking of the Phe3 residue to different domains of the opioid receptors. J Comput Aided Mol Des. 1996 Jun;10(3):201-12. PubMed PMID: 8808737.8: Lomize AL, Pogozheva ID, Mosberg HI. Development of a model for the delta-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH with other conformationally constrained delta-receptor selective ligands. Biopolymers. 1996 Feb;38(2):221-34. PubMed PMID: 8589255.9: Deschamps JR, George C, Flippen-Anderson JL. Structural studies of opioid peptides: a review of recent progress in x-ray diffraction studies. Biopolymers. 1996;40(1):121-39. Review. PubMed PMID: 8541444.10: Mosberg HI, Omnaas JR, Lomize A, Heyl DL, Nordan I, Mousigian C, Davis P, Porreca F. Development of a model for the delta opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). J Med Chem. 1994 Dec 9;37(25):4384-91. PubMed PMID: 7996550.1

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