147395-65-1|JL 18|8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine|-范德生物科技公司

JL 18

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names：
8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine
CAS号：
147395-65-1
MDL Number：
MF(分子式)： C18H21N5 MW(分子量)： 307.401
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	JL 18
英文别名	JL 18; JL-18; JL18
CAS号	147395-65-1
SMILES	CN1CCN(C2=NC3=CC=CN=C3NC4=CC=C(C)C=C24)CC1
Inchi	InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)
InchiKey	MMCMKWDIEUZMQB-UHFFFAOYSA-N
分子式 Formula	C18H21N5
分子量 Molecular Weight	307.401
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	JL 18(CAS:147395-65-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	JL 18 is a pyridobenzodiazepine derivative bioisoster of clozapine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Shionoya T, Mizuno M, Tsukamoto T, Ikeda K, Seki H, Kojima K, Shibata M, Kawamura I, Sudo Y, Mizutani Y. High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment. J Phys Chem B. 2018 Jul 12;122(27):6945-6953. doi: 10.1021/acs.jpcb.8b04894. Epub 2018 Jun 27. PubMed PMID: 29893559.

[2]Tsukamoto T, Mizutani K, Hasegawa T, Takahashi M, Honda N, Hashimoto N, Shimono K, Yamashita K, Yamamoto M, Miyauchi S, Takagi S, Hayashi S, Murata T, Sudo Y. X-ray Crystallographic Structure of Thermophilic Rhodopsin: IMPLICATIONS FOR HIGH THERMAL STABILITY AND OPTOGENETIC FUNCTION. J Biol Chem. 2016 Jun 3;291(23):12223-32. doi: 10.1074/jbc.M116.719815. Epub 2016 Apr 18. PubMed PMID: 27129243; PubMed Central PMCID: PMC4933271.

[3] Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han C, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Pati A, Goodwin L, Peters L, Pitluck S, Lam J, McDonald AI, Dodsworth JA, Woyke T, Hedlund BP. Thermus oshimai JL-2 and T. thermophilus JL-18 genome analysis illuminates pathways for carbon, nitrogen, and sulfur cycling. Stand Genomic Sci. 2013 Feb 25;7(3):449-68. doi: 10.4056/sigs.3667269. eCollection 2013. PubMed PMID: 24019992; PubMed Central PMCID: PMC3764938.

[4] Murugapiran SK, Huntemann M, Wei CL, Han J, Detter JC, Han CS, Erkkila TH, Teshima H, Chen A, Kyrpides N, Mavrommatis K, Markowitz V, Szeto E, Ivanova N, Pagani I, Lam J, McDonald AI, Dodsworth JA, Pati A, Goodwin L, Peters L, Pitluck S, Woyke T, Hedlund BP. Whole Genome Sequencing of Thermus oshimai JL-2 and Thermus thermophilus JL-18, Incomplete Denitrifiers from the United States Great Basin. Genome Announc. 2013 Jan;1(1). pii: e00106-12. doi: 10.1128/genomeA.00106-12. Epub 2013 Jan 24. PubMed PMID: 23405355; PubMed Central PMCID: PMC3569359.

[5] Morishita H, Shibata K, Sakata N, Kita S, Katsuragi T. A new approach to finding specific dopamine D4 receptor agonists. Eur J Pharmacol. 2005 Jun 1;516(2):145-50. PubMed PMID: 15922324.

6: Hadj Tahar A, Bélanger N, Bangassoro E, Grégoire L, Bédard PJ. Antidyskinetic effect of JL-18, a clozapine analog, in parkinsonian monkeys. Eur J Pharmacol. 2000 Jul 7;399(2-3):183-6. PubMed PMID: 10884518.7: Morishita H, Katsuragi T. Existence and pharmacological properties of dopamine D4 receptors in guinea pig vas deferens. Eur J Pharmacol. 1999 Jun 18;374(2):255-61. PubMed PMID: 10422767.8: Carey GJ, Bergman J. Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs. Psychopharmacology (Berl). 1997 Aug;132(3):261-9. PubMed PMID: 9292626.9: Liégeois JF, Bruhwyler J, Damas J, Rogister F, Masereel B, Geczy J, Delarge J. Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor. Eur J Pharmacol. 1995 Feb 6;273(3):R1-3. PubMed PMID: 7737323.

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