198279-45-7|J-104132|(5S,6R,7R)-5-(benzo[d][1,3]dioxol-5-yl)-2-butyl-7-(2-((S)-2-carboxypropyl)-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid|-范德生物科技公司

J-104132

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names：
(5S,6R,7R)-5-(benzo[d][1,3]dioxol-5-yl)-2-butyl-7-(2-((S)-2-carboxypropyl)-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CAS号：
198279-45-7
MDL Number：
MF(分子式)： C31H33NO7 MW(分子量)： 531.605
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	J-104132
英文别名	J-104132; J104132; J 104132; L-753037; L 753037; L753037.
CAS号	198279-45-7
SMILES	O=C([C@@H]1[C@@H](C2=CC=C(OCO3)C3=C2)C4=CC=C(CCCC)N=C4[C@H]1C5=CC=C(OC)C=C5C[C@@H](C(O)=O)C)O
Inchi	InChI=1S/C31H33NO7/c1-4-5-6-20-8-10-23-26(18-7-12-24-25(15-18)39-16-38-24)28(31(35)36)27(29(23)32-20)22-11-9-21(37-3)14-19(22)13-17(2)30(33)34/h7-12,14-15,17,26-28H,4-6,13,16H2,1-3H3,(H,33,34)(H,35,36)/t17-,26-,27-,28+/m0/s1
InchiKey	IUHMIOAKWHUFKU-YINIXLNUSA-N
分子式 Formula	C31H33NO7
分子量 Molecular Weight	531.605
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	J-104132(CAS:198279-45-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	J-104132, also known as L-753037, is a potetn and selective endothelin A/B receptor antagonist potentially for the treatment of heart failure. J-104132 has Ki cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM. In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ovary cells stably expressing cloned human ETA receptors (IC50 = 0.059 nM). Pretreatment with J-104132 prevents the lethal response to ET-1 when administered i.v. (ED50 = 0.045 mg/kg) or p.o. in fed animals (ED50 = 0.35 mg/kg). J-104132 is an excellent pharmacological tool to explore the therapeutic use of a mixed ETA/ETB receptor antagonist.
Application1
Application2
Application3

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危险性	Warning
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安全声明
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备注

[1]Kitada K, Yui N, Mori T, Ohkita M, Matsumura Y. Vasoprotective effects of an endothelin receptor antagonist in ovariectomized female rats. Life Sci. 2014 Nov 24;118(2):379-85. doi: 10.1016/j.lfs.2014.01.009. PubMed PMID: 24468711.

[2]Kitada K, Yui N, Koyama M, Kimura K, Suzuki R, Tanaka R, Mori T, Ohkita M, Matsumura Y. Endothelin ETB receptor is involved in sex differences in the development of balloon injury-induced neointimal formation. J Pharmacol Exp Ther. 2011 Feb;336(2):533-9. doi: 10.1124/jpet.109.165308. PubMed PMID: 21075838.

[3] Kitada K, Yui N, Matsumoto C, Mori T, Ohkita M, Matsumura Y. Inhibition of endothelin ETB receptor system aggravates neointimal hyperplasia after balloon injury of rat carotid artery. J Pharmacol Exp Ther. 2009 Dec;331(3):998-1004. doi: 10.1124/jpet.109.157065. PubMed PMID: 19737855.

[4] Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, McMurtry IF, Oka M. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol. 2007 Dec;50(6):697-702. PubMed PMID: 18091588.

[5] Tani T, Gram LK, Arakawa H, Kikuchi A, Chiba M, Ishii Y, Steffansen B, Tamai I. Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats. Pharm Res. 2008 May;25(5):1085-91. PubMed PMID: 17957449.

6: Kamata K, Kanie N, Matsumoto T, Kobayashi T. Endothelin-1-induced impairment of endothelium-dependent relaxation in aortas isolated from controls and diabetic rats. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S186-90. PubMed PMID: 15838275.7: Krause SM, Clayton FC, Williams DL Jr. Myocardial protection with the non-selective endothelin receptor antagonist L-753,037 following acute coronary artery occlusion in the dog. J Cardiovasc Pharmacol. 2004 Feb;43(2):214-21. PubMed PMID: 14716208.8: Kobayashi N, Tani T, Hisaka A, Hara K, Yasumori T. Hepatobiliary transport of a nonpeptidic endothelin antagonist, (+)-(5S,6R,7R)-2-butyl-7-[2((2S)-2-carboxypropyl)-4-methoxyphenyl]-5-(3,4-methyle nedioxyphenyl) cyclopentenol[1,2-b]pyridine-6-carboxylic acid: uptake by isolated rat hepatocytes and canalicular membrane vesicles. Pharm Res. 2003 Jan;20(1):89-95. PubMed PMID: 12608541.9: Kanie N, Kamata K. Effects of chronic administration of the novel endothelin antagonist J-104132 on endothelial dysfunction in streptozotocin-induced diabetic rat. Br J Pharmacol. 2002 Apr;135(8):1935-42. PubMed PMID: 11959796; PubMed Central PMCID: PMC1573322.10: Aleksic S, Szabo Z, Scheffel U, Ravert HT, Mathews WB, Kerenyi L, Rauseo PA, Gibson RE, Burns HD, Dannals RF. In vivo labeling of endothelin receptors with [(11)C]L-753,037: studies in mice and a dog. J Nucl Med. 2001 Aug;42(8):1274-80. PubMed PMID: 11483691.1

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