173959-12-1|IT-9302|L-alanyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-lysyl-L-isoleucyl-L-arginyl-L-asparagine|-范德生物科技公司

IT-9302

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names：
L-alanyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-lysyl-L-isoleucyl-L-arginyl-L-asparagine
CAS号：
173959-12-1
MDL Number：
MF(分子式)： C48H82N14O13S2 MW(分子量)： 1127.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	IT-9302
英文别名	IT-9302; IT 9302; IT9302;
CAS号	173959-12-1
Inchi	InChI=1S/C48H82N14O13S2/c1-7-25(2)37(45(72)57-31(12-10-20-54-48(52)53)40(67)60-35(47(74)75)24-36(51)65)61-42(69)30(11-8-9-19-49)55-41(68)32(17-21-76-5)58-46(73)38(27(4)63)62-43(70)33(18-22-77-6)56-44(71)34(59-39(66)26(3)50)23-28-13-15-29(64)16-14-28/h13-16,25-27,30-35,37-38,63-64H,7-12,17-24,49-50H2,1-6H3,(H2,51,65)(H,55,68)(H,56,71)(H,57,72)(H,58,73)(H,59,66)(H,60,67)(H,61,69)(H,62,70)(H,74,75)(H4,52,53,54)/t25-,26-,27+,30-,31-,32-,33-,34-,35-,37-,38-/m0/s1
InchiKey	GTORPNRZTBKYJB-AIEIIIEWSA-N
分子式 Formula	C48H82N14O13S2
分子量 Molecular Weight	1127.38
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	IT-9302(CAS:173959-12-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	IT-9302 is a synthetic interleukin-10 agonist; diminishes acute lung injury in rabbits.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]López MN, Pesce B, Kurte M, Pérez C, Segal G, Roa J, Aguillón JC, Mendoza-Naranjo A, Gesser B, Larsen C, Villablanca A, Choudhury A, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ tolerogenic dendritic cells. Immunobiology. 2011 Oct;216(10):1117-26. doi: 10.1016/j.imbio.2011.04.006. Epub 2011 Apr 22. PubMed PMID: 21601308.

[2]Salazar-Onfray F, López MN, Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):171-82. Epub 2007 Feb 27. Review. PubMed PMID: 17329145.

[3] Kurte M, López M, Aguirre A, Escobar A, Aguillón JC, Charo J, Larsen CG, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells. J Immunol. 2004 Aug 1;173(3):1731-7. PubMed PMID: 15265902.

[4] Osman MO, Gesser B, Mortensen JT, Matsushima K, Jensen SL, Larsen CG. Profiles of pro-inflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis. Cytokine. 2002 Jan 7;17(1):53-9. PubMed PMID: 11886171.

[5] Vestergaard C, Kirstejn N, Gesser B, Mortensen JT, Matsushima K, Larsen CG. IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis. J Dermatol Sci. 2001 May;26(1):46-54. PubMed PMID: 11323220.

6: Osman MO, Jacobsen NO, Kristensen JU, Deleuran B, Gesser B, Larsen CG, Jensen SL. IT 9302, a synthetic interleukin-10 agonist, diminishes acute lung injury in rabbits with acute necrotizing pancreatitis. Surgery. 1998 Sep;124(3):584-92. PubMed PMID: 9736913.

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