77900-75-5|Isosulfazecin|N5-((S)-1-amino-1-oxopropan-2-yl)-N5-((R)-3-methoxy-2-oxo-1-sulfoazetidin-3-yl)-D-glutamine|-范德生物科技公司

Isosulfazecin

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names：
N5-((S)-1-amino-1-oxopropan-2-yl)-N5-((R)-3-methoxy-2-oxo-1-sulfoazetidin-3-yl)-D-glutamine
CAS号：
77900-75-5
MDL Number：
MF(分子式)： C12H20N4O9S MW(分子量)： 396.3
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK16474-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Isosulfazecin
英文别名	Isosulfazecin;
CAS号	77900-75-5
Inchi	InChI=1S/C12H20N4O9S/c1-6(9(14)18)16(8(17)4-3-7(13)10(19)20)12(25-2)5-15(11(12)21)26(22,23)24/h6-7H,3-5,13H2,1-2H3,(H2,14,18)(H,19,20)(H,22,23,24)/t6-,7+,12+/m0/s1
InchiKey	XRFHRUFVTGBKHE-QRPMWFLTSA-N
分子式 Formula	C12H20N4O9S
分子量 Molecular Weight	396.3
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Isosulfazecin(CAS:77900-75-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Isosulfazecin is a beta-lactam antibiotic, produced by an acidophilic pseudomonad.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Oliver RA, Li R, Townsend CA. Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase. Nat Chem Biol. 2018 Jan;14(1):5-7. doi: 10.1038/nchembio.2526. Epub 2017 Nov 20. PubMed PMID: 29155429; PubMed Central PMCID: PMC5726899.

[2]Horsman ME, Marous DR, Li R, Oliver RA, Byun B, Emrich SJ, Boggess B, Townsend CA, Mobashery S. Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster. ACS Chem Biol. 2017 Oct 20;12(10):2552-2557. doi: 10.1021/acschembio.7b00687. Epub 2017 Sep 26. PubMed PMID: 28937735; PubMed Central PMCID: PMC5653948.

[3] Loveridge EJ, Jones C, Bull MJ, Moody SC, Kahl MW, Khan Z, Neilson L, Tomeva M, Adams SE, Wood AC, Rodriguez-Martin D, Pinel I, Parkhill J, Mahenthiralingam E, Crosby J. Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex. J Bacteriol. 2017 Jun 13;199(13). pii: e00125-17. doi: 10.1128/JB.00125-17. Print 2017 Jul 1. PubMed PMID: 28439036; PubMed Central PMCID: PMC5472815.

[4] Braga D, Lackner G. One Ring to Fight Them All: The Sulfazecin Story. Cell Chem Biol. 2017 Jan 19;24(1):1-2. doi: 10.1016/j.chembiol.2017.01.001. PubMed PMID: 28107651.

[5] Li R, Oliver RA, Townsend CA. Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster. Cell Chem Biol. 2017 Jan 19;24(1):24-34. doi: 10.1016/j.chembiol.2016.11.010. Epub 2016 Dec 22. PubMed PMID: 28017601; PubMed Central PMCID: PMC5286544.

6: Box SJ, Brown AG, Gilpin ML, Gwynn MN, Spear SR. MM 42842, a new member of the monobactam family produced by Pseudomonas cocovenenans. II. Production, isolation and properties of MM 42842. J Antibiot (Tokyo). 1988 Jan;41(1):7-12. PubMed PMID: 3346195.7: Parker WL, O'Sullivan J, Sykes RB. Naturally occurring monobactams. Adv Appl Microbiol. 1986;31:181-205. Review. PubMed PMID: 3521210.8: Okonogi K, Sugiura A, Kuno M, Ono H, Harada S, Higashide E. Interactions of formylamino- and methoxy-substituted beta-lactam antibiotics with beta-lactamases. J Antibiot (Tokyo). 1985 Nov;38(11):1555-63. PubMed PMID: 3878359.9: Imada A, Kondo M, Okonogi K, Yukishige K, Kuno M. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7. PubMed PMID: 3874598; PubMed Central PMCID: PMC180159.10: Sendai M, Hashiguchi S, Tomimoto M, Kishimoto S, Matsuo T, Kondo M, Ochiai M. Chemical modification of sulfazecin. Synthesis of 4-(substituted methyl)-2-azetidinone-1-sulfonic acid derivatives. J Antibiot (Tokyo). 1985 Mar;38(3):346-71. PubMed PMID: 4008329.1

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