117027-34-6|Interleukin 1beta|L-Threonine, N-(1-L-lysyl-D-prolyl)-|-范德生物科技公司

Interleukin 1beta

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names：
L-Threonine, N-(1-L-lysyl-D-prolyl)-
CAS号：
117027-34-6
MDL Number：
MF(分子式)： C15H28N4O5 MW(分子量)： 344.412
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Interleukin 1beta
英文别名	Interleukin 1beta
CAS号	117027-34-6
SMILES	C[C@@H](O)[C@@H](C(O)=O)NC([C@@H]1N(C([C@H](CCCCN)N)=O)CCC1)=O
Inchi	InChI=1S/C15H28N4O5/c1-9(20)12(15(23)24)18-13(21)11-6-4-8-19(11)14(22)10(17)5-2-3-7-16/h9-12,20H,2-8,16-17H2,1H3,(H,18,21)(H,23,24)/t9-,10+,11-,12+/m1/s1
InchiKey	LOGFVTREOLYCPF-KXNHARMFSA-N
分子式 Formula	C₁₅H₂₈N₄O₅
分子量 Molecular Weight	344.412
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Interleukin 1beta(CAS:117027-34-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Interleukin 1beta is a bioactive chemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nan K, Han Y, Fang Q, Huang C, Yu L, Ge W, Xiang F, Tao YX, Cao H, Li J. HMGB1 gene silencing inhibits neuroinflammation via down-regulation of NF-κB signaling in primary hippocampal neurons induced by Aβ(25-35). Int Immunopharmacol. 2018 Dec 17;67:294-30[1]doi: 10.1016/j.intimp.2018.12.027. [Epub ahead of print] PubMed PMID: 30572254.

[2]Hu X, Shen H, Wang Y, Zhang L, Zhao M. Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice. Life Sci. 2018 Dec 17. pii: S0024-3205(18)30821-X. doi: 10.1016/j.lfs.2018.12.028. [Epub ahead of print] PubMed PMID: 30571954.

[3] Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca(2+)/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 Nov 27;138(22):2530-2544. doi: 10.1161/CIRCULATIONAHA.118.034621. PubMed PMID: 30571348.

[4] Kim ML, Martin WJ, Minigo G, Keeble JL, Garnham AL, Pacini G, Smyth GK, Speed TP, Carapetis J, Wicks IP. Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine. Circulation. 2018 Dec 4;138(23):2648-2661. doi: 10.1161/CIRCULATIONAHA.118.033891. PubMed PMID: 30571257.

[5] Wang W, Zhong X, Li Y, Guo R, Du S, Wen L, Ying Y, Yang T, Wei XH. Rostral ventromedial medulla-mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic postoperative pain. J Neurochem. 2018 Dec 20. doi: 10.1111/jnc.14650. [Epub ahead of print] PubMed PMID: 30570747.

6: Liu H, Dong H, Zhou N, Dong S, Chen L, Zhu Y, Hu HM, Mou Y. SPIO Enhance the Cross-Presentation and Migration of DCs and Anionic SPIO Influence the Nanoadjuvant Effects Related to Interleukin-1β. Nanoscale Res Lett. 2018 Dec 20;13(1):409. doi: 10.1186/s11671-018-2802-0. PubMed PMID: 30570682.7: Li Q, Ye T, Long T, Peng X. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2018 Dec 20:1-9. doi: 10.1080/09168451.2018.1553608. [Epub ahead of print] PubMed PMID: 30570395.8: Lee Y, Pham TX, Bae M, Hu S, O'Neill E, Chun OK, Han MJ, Koo SI, Park YK, Lee JY. Blackcurrant (Ribes nigrum) Prevents Obesity-Induced Nonalcoholic Steatohepatitis in Mice. Obesity (Silver Spring). 2019 Jan;27(1):112-120. doi: 10.1002/oby.22353. PubMed PMID: 30569636.9: Ren S, Chen X, Huang R, Zhou GG, Yuan Z. SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model. Oncol Rep. 2018 Dec 18. doi: 10.3892/or.2018.6935. [Epub ahead of print] PubMed PMID: 30569160.10: Wang S, Ji LY, Li L, Li JM. Oxidative stress, autophagy and pyroptosis in the neovascularization of oxygen induced retinopathy in mice. Mol Med Rep. 2018 Dec 13. doi: 10.3892/mmr.2018.9759. [Epub ahead of print] PubMed PMID: 30569132.1

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