161522-25-4|HSR-609|3-(4-(8-fluorobenzo[6,7]oxepino[4,3-b]pyridin-11(5H)-ylidene)piperidin-1-yl)propanoic acid|-范德生物科技公司

HSR-609

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names：
3-(4-(8-fluorobenzo[6,7]oxepino[4,3-b]pyridin-11(5H)-ylidene)piperidin-1-yl)propanoic acid
CAS号：
161522-25-4
MDL Number：
MF(分子式)： C21H21FN2O3 MW(分子量)： 368.4084
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	HSR-609
英文别名	FY-609; HSR-609; FY 609; HSR 609; FY609; HSR609.
CAS号	161522-25-4
Inchi	InChI=1S/C21H21FN2O3/c22-16-3-4-17-18(12-16)27-13-15-2-1-8-23-21(15)20(17)14-5-9-24(10-6-14)11-7-19(25)26/h1-4,8,12H,5-7,9-11,13H2,(H,25,26)
InchiKey	VNMVYPKXIOJAGS-UHFFFAOYSA-N
分子式 Formula	C21H21FN2O3
分子量 Molecular Weight	368.4084
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	HSR-609(CAS:161522-25-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	HSR-609, also known FY-609, is a histamine H1 receptor antagonist potentially for the treatment of allergic rhinitis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Salmun LM. Antihistamines in late-phase clinical development for allergic disease. Expert Opin Investig Drugs. 2002 Feb;11(2):259-73. Review. PubMed PMID: 11829715.

[2]Musoh K, Nakamura N, Nagai H. Effects of an amphoteric antiallergic agent, HSR-609, on antigen-induced late phase nasal eosinophilia in brown Norway rats. Pharmacology. 2000 Nov;61(4):230-7. PubMed PMID: 11093074.

[3] Musoh K, Maeda Y, Tanaka H, Inagaki N, Nagai H. Effect of a novel anti-allergic agent, HSR-609, on antigen-induced airway hyperresponsiveness in mice. Pharmacology. 2000 Aug;61(2):70-7. PubMed PMID: 10940779.

[4] Kakiuchi M, Ohashi T, Tanaka K, Ohara N, Kamiyama K, Morikawa K, Kato H. Central nervous system effects of the novel antiallergic agent HSR-609 and typical antiallergic agents using behavioral and electroencephalographic analyses in dogs. Nihon Shinkei Seishin Yakurigaku Zasshi. 1998 Oct;18(5):189-99. PubMed PMID: 10028490.

[5] Kakiuchi M, Ohashi T, Tanaka K, Kamiyama K, Morikawa K, Kato H. Pharmacological studies on the novel antiallergic agent HSR-609: its effects on behavior in mice and electroencephalograms in rabbits. Jpn J Pharmacol. 1997 Sep;75(1):43-57. PubMed PMID: 9334885.

6: Kakiuchi M, Ohashi T, Musoh K, Kawamura K, Morikawa K, Kato H. Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor. Jpn J Pharmacol. 1997 Apr;73(4):291-8. PubMed PMID: 9165365.7: Hasegawa H, Takahara E, Yamada T, Nagata O. Sensitive analytical method for the novel H1-receptor antagonist HSR-609 in human plasma and urine by high-performance liquid chromatography with pre-column fluorescent derivatization. J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):419-25. PubMed PMID: 9017466.8: Iwasaki N, Ohashi T, Musoh K, Nishino H, Kado N, Yasuda S, Kato H, Ito Y. Amphoteric drugs. 3. Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11- ylidene)piperidino]propionic acid derivatives and related compounds. J Med Chem. 1995 Feb 3;38(3):496-507. PubMed PMID: 7853343.

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