13080-21-2|HPi1|3-Hydrazinoquinoxaline-2-thiol|-范德生物科技公司

HPi1

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names：
3-Hydrazinoquinoxaline-2-thiol
CAS号：
13080-21-2
MDL Number：
MF(分子式)： C8H8N4S MW(分子量)： 192.24
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	HPi1
英文别名	HPi1; HPi-1; HPi 1; GlmU-IN-5215319; GlmU IN 5215319; GlmUIN5215319; GlmU inhibitor 5215319;
CAS号	13080-21-2
SMILES	SC1=NC2=CC=CC=C2N=C1NN
Inchi	InChI=1S/C8H8N4S/c9-12-7-8(13)11-6-4-2-1-3-5(6)10-7/h1-4H,9H2,(H,10,12)(H,11,13)
InchiKey	TVYAHCDRRICQJM-UHFFFAOYSA-N
分子式 Formula	C8H8N4S
分子量 Molecular Weight	192.24
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	HPi1(CAS:13080-21-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	HPi1 is a selective antimicrobial against helicobacter pylori. It acts as an inhibitor of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kaur G, Reinhart RA, Monks A, Evans D, Morris J, Polley E, Teicher BA. Bromodomain and hedgehog pathway targets in small cell lung cancer. Cancer Lett. 2016 Feb 28;371(2):225-39. doi: 10.1016/j.canlet.2015.12.00[1]Epub 2015 Dec 10. PubMed PMID: 26683772; PubMed Central PMCID: PMC4738144.

[2]Gavrish E, Shrestha B, Chen C, Lister I, North EJ, Yang L, Lee RE, Han A, Williams B, Charnuska D, Coleman K, Lewis K, LaFleur MD. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60. doi: 10.1128/AAC.02573-13. Epub 2014 Mar 31. PubMed PMID: 24687512; PubMed Central PMCID: PMC4068456.

[3] Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul;39(5):645-51. doi: 10.1016/j.nucmedbio.2011.12.001. Epub 2012 Feb 10. PubMed PMID: 22316614; PubMed Central PMCID: PMC3361517.

[4] Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm. 2011 Jun 6;8(3):767-73. doi: 10.1021/mp100382m. Epub 2011 Apr 21. PubMed PMID: 21361360; PubMed Central PMCID: PMC3109173.

[5] Yoshii T, Kuji N, Komatsu S, Iwahashi K, Tanaka Y, Yoshida H, Wada A, Yoshimura Y. Fine resolution of human sperm nucleoproteins by two-dimensional electrophoresis. Mol Hum Reprod. 2005 Sep;11(9):677-81. Epub 2005 Sep 28. PubMed PMID: 16192297.

6: Matesic LE, Niemitz EL, De Maio A, Reeves RH. Quantitative trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation. FASEB J. 2000 Nov;14(14):2247-54. PubMed PMID: 11053246.7: Prigent Y, Troalen F, Dadoune JP. Immunoelectron microscopic visualization of intermediate basic proteins HPI1 and HPI2 in human spermatids and spermatozoa. Reprod Nutr Dev. 1998 Jul-Aug;38(4):417-27. PubMed PMID: 9795985.8: Lin WY, Wang SJ, Yeh SH. Hepatic perfusion index in evaluating treatment effect of transcatheter hepatic artery embolization in patients with hepatocellular carcinoma. Neoplasma. 1995;42(2):89-92. PubMed PMID: 7617083.9: Alimi E, Martinage A, Arkhis A, Belaiche D, Sautiere P, Chevaillier P. Amino acid sequence of the human intermediate basic protein 2 (HPI2) from sperm nuclei. Structural relationship with protamine P2. Eur J Biochem. 1993 Jun 1;214(2):445-50. PubMed PMID: 8513794.10: Martinage A, Arkhis A, Alimi E, Sautière P, Chevaillier P. Molecular characterization of nuclear basic protein HPI1, a putative precursor of human sperm protamines HP2 and HP3. Eur J Biochem. 1990 Jul 31;191(2):449-51. PubMed PMID: 2384091.1

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