18920-47-3|Helioxanthin|10-(benzo[d][1,3]dioxol-5-yl)furo[3',4'6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one|-范德生物科技公司

Helioxanthin

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names：
10-(benzo[d][1,3]dioxol-5-yl)furo[3',4'6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one
CAS号：
18920-47-3
MDL Number：
MF(分子式)： C20H12O6 MW(分子量)： 348.31
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Helioxanthin
英文别名	HE-145; HE 145; HE145. Helioxanthin
CAS号	18920-47-3
Inchi	InChI=1S/C20H12O6/c21-20-12-5-10-2-4-15-19(26-9-24-15)18(10)17(13(12)7-22-20)11-1-3-14-16(6-11)25-8-23-14/h1-6H,7-9H2
InchiKey	JUBRYHUFFFYTGR-UHFFFAOYSA-N
分子式 Formula	C20H12O6
分子量 Molecular Weight	348.31
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Helioxanthin(CAS:18920-47-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Helioxanthin, also known as HE-145, is a potent inhibitor of HBV, HCV and HSV-1 virus. Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice. Helioxanthin inhibits interleukin-1 beta-induced MIP-1 beta production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1/CRE site of the MIP-1 beta promoter in Huh7 cells.
Application1
Application2
Application3

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危险性	Warning
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安全声明
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备注

[1]Janmanchi D, Lin CH, Hsieh JY, Tseng YP, Chen TA, Jhuang HJ, Yeh SF. Synthesis and biological evaluation of helioxanthin analogues. Bioorg Med Chem. 2013 Apr 1;21(7):2163-76. doi: 10.1016/j.bmc.2012.11.037. Epub 2012 Dec 5. PubMed PMID: 23465436.

[2]Lin YM, Kuo WW, Velmurugan BK, Hsien HH, Hsieh YL, Hsu HH, Tu CC, Bau DT, Viswanadha VP, Huang CY. Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice. Environ Toxicol. 2015 Oct 14. doi: 10.1002/tox.22204. [Epub ahead of print] PubMed PMID: 26464283.

[3] Kao TT, Lin CC, Shia KS. The Total Synthesis of Retrojusticidin B, Justicidin E, and Helioxanthin. J Org Chem. 2015 Jul 2;80(13):6708-14. doi: 10.1021/acs.joc.5b00866. Epub 2015 Jun 15. PubMed PMID: 26047161.

[4] Li Y, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, Cheng YC. Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201. PubMed PMID: 16004082.

[5] Ying C, Tan S, Cheng YC. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103. doi: 10.3851/IMP1686. PubMed PMID: 21107018.

6: Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Ihara S, Aburatani H, Takato T, Chung UI. Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun. 2010 May 14;395(4):502-8. doi: 10.1016/j.bbrc.2010.04.041. Epub 2010 Apr 9. Erratum in: Biochem Biophys Res Commun. 2010 Jul 2;397(3):631. Ihara, Sigeo [added]. PubMed PMID: 20382113.7: Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun. 2007 Jun 15;357(4):854-60. Epub 2007 Apr 9. PubMed PMID: 17451649.8: Yeo H, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46. PubMed PMID: 15658867.9: Song Y, Deng Y, Huang D, Wen J, Liu Z, Li F. LC-MS/MS determination and pharmacokinetic study of four lignan components in rat plasma after oral administration of Acanthopanax sessiliflorus extract. J Ethnopharmacol. 2012 Jun 14;141(3):957-63. doi: 10.1016/j.jep.2012.03.034. Epub 2012 Apr 4. PubMed PMID: 22497733.10: Tseng PC, Hsu HC, Janmanchi D, Lin CH, Kuo YH, Chou CK, Yeh SF. Helioxanthin inhibits interleukin-1 beta-induced MIP-1 beta production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1/CRE site of the MIP-1 beta promoter in Huh7 cells. Biochem Pharmacol. 2008 Oct 30;76(9):1121-33. doi: 10.1016/j.bcp.2008.08.023. Epub 2008 Aug 27. PubMed PMID: 18789903.1

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