924296-39-9|HBX-41108|7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile|-范德生物科技公司

HBX-41108

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names：
7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
CAS号：
924296-39-9
MDL Number：
MF(分子式)： C13H3ClN4O MW(分子量)： 266.644
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK15981-1g	1g	>98%	¥ 51100.00	¥ 51100.00		2 Weeks	- +	¥ 0.00

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询价

中文别名	HBX-41108
英文别名	HBX 41108; HBX-41108; HBX41108; HBX 41,108; HBX-41,108; HBX41,108.
CAS号	924296-39-9
Inchi	InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
InchiKey	BIGPXXAUSQLTQR-UHFFFAOYSA-N
分子式 Formula	C13H3ClN4O
分子量 Molecular Weight	266.644
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	HBX-41108(CAS:924296-39-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Nicholson B, Suresh Kumar KG. The multifaceted roles of USP7: new therapeuticopportunities. Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi:10.1007/s12013-011-9185-5. Review. PubMed PMID: 21468693.

[2]Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, TrouplinV, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, ColluraV, Boissy G, Rain JC, Guedat P, Delansorne R, Daviet L. Small-molecule inhibitorof USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. MolCancer Ther. 2009 Aug;8(8):2286-95. doi: 10.1158/1535-7163.MCT-09-0097. Epub 2009Aug 11. PubMed PMID: 19671755.

[3] Lee KW, Cho JG, Kim CM, Kang AY, Kim M, Ahn BY, Chung SS, Lim KH, Baek KH,Sung JH, Park KS, Park SG. Herpesvirus-associated ubiquitin-specific protease(HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stabilitythrough its deubiquitinating activity. J Biol Chem. 2013 Nov 15;288(46):32886-96.doi: 10.1074/jbc.M113.496331. Epub 2013 Sep 26. PubMed PMID: 24072712; PubMedCentral PMCID: PMC3829140.

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