957011-15-3|HBF-0259|7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine|-范德生物科技公司

HBF-0259

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names：
7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
CAS号：
957011-15-3
MDL Number：
MF(分子式)： C16H12Cl2FN5 MW(分子量)： 364.2054
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	HBF-0259
英文别名	HBF-0259; HBF 0259; HBF0259.
CAS号	957011-15-3
Inchi	InChI=1S/C16H12Cl2FN5/c17-10-6-4-9(5-7-10)13-8-14(24-16(20-13)21-22-23-24)15-11(18)2-1-3-12(15)19/h1-7,13-14H,8H2,(H,20,21,23)
InchiKey	BRBZPYDLUUWBCD-UHFFFAOYSA-N
分子式 Formula	C16H12Cl2FN5
分子量 Molecular Weight	364.2054
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	HBF-0259(CAS:957011-15-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	HBF-0259 is a novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. HBF-0259 was identified to inhibit HBsAg with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a 50% effective concentration of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.
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危险性	Warning
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备注

[1]Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE,Zhao K, Block TM, Cuconati A, Xu X. Design, synthesis, and biological evaluationof triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virussurface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54(16):5660-70. doi:10.1021/jm200696v. Epub 2011 Aug 2. PubMed PMID: 21786803; PubMed Central PMCID:PMC3158247.

[2]Dougherty AM, Guo H, Westby G, Liu Y, Simsek E, Guo JT, Mehta A, Norton P, GuB, Block T, Cuconati A. A substituted tetrahydro-tetrazolo-pyrimidine is aspecific and novel inhibitor of hepatitis B virus surface antigen secretion.Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. Epub 2007 Sep 17. PubMedPMID: 17875990; PubMed Central PMCID: PMC2167973.

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