161832-71-9|GYKI-53784|(R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4',5'4,5]benzo[1,2-d][1,2]diazepine-7-carboxamide|-范德生物科技公司

GYKI-53784

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names：
(R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4',5'4,5]benzo[1,2-d][1,2]diazepine-7-carboxamide
CAS号：
161832-71-9
MDL Number：
MF(分子式)： C19H20N4O3 MW(分子量)： 352.394
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	GYKI-53784
英文别名	GYKI-53784; GYKI53784; GYKI 53784; LY 303070; LY-303070; LY303070.
CAS号	161832-71-9
Inchi	InChI=1S/C19H20N4O3/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24)/t11-/m1/s1
InchiKey	SMGACXZFVXKEAX-LLVKDONJSA-N
分子式 Formula	C19H20N4O3
分子量 Molecular Weight	352.394
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	GYKI-53784(CAS:161832-71-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	GYKI-53784, also known as LY 303070, is a potent and selective AMPA receptor antagonist. GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea. GYKI 53784 had the same potency as DNQX and was 10 times more potent than GYKI 52466 in reducing auditory nerve activity. GYKI 53784 completely blocked excitotoxicity (i.e. destruction of the afferent nerve endings) induced by AMPA and kainate. The histochemical detection of Co(2+) uptake was used to study Ca(2+) influx within the primary auditory nerve cells.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ruel J, Guitton MJ, Puell JL. Negative allosteric modulation ofAMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), aspecific non-competitive AMPA antagonist. CNS Drug Rev. 2002 Fall;8(3):235-54.Review. PubMed PMID: 12353057.

[2]Ruel J, Bobbin RP, Vidal D, Pujol R, Puel JL. The selective AMPA receptorantagonist GYKI 53784 blocks action potential generation and excitotoxicity inthe guinea pig cochlea. Neuropharmacology. 2000 Aug 23;39(11):1959-73. PubMedPMID: 10963740.

[3] Kapus G, Bódi I, Pataki A, Gueritaud J, Székely JI, Tarnawa I. Differentialmodulation of the GYKI 53784-induced inhibition of AMPA currents by variousAMPA-positive modulators in cerebellar Purkinje cells. Eur J Pharmacol. 2000 May26;397(1):43-7. PubMed PMID: 10844097.

[4] Ruiz A, Durand J. Modulation of kainate-induced responses by pentobarbitoneand GYKI-53784 in rat abducens motoneurons in vivo. Brain Res. 1999 Feb13;818(2):421-30. PubMed PMID: 10082828.

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