1020412-43-4|Gardiquimod|Gardiquimod, toll-like receptor 7 (TLR7) agonist|-范德生物科技公司

Gardiquimod

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names：
Gardiquimod, toll-like receptor 7 (TLR7) agonist
CAS号：
1020412-43-4
MDL Number：
MF(分子式)： C17H23N5O MW(分子量)： 313.4
EINECS:Not available Reaxys Number:No data available
Pubchem ID:44592366 Brand:BIOFOUNT

加地喹莫特是人类toll样受体7（TLR7）的激动剂，但不是人类TLR8，尽管它同时激活猪TLR7和TLR8。在0.5至2μg/ ml时，它增强了T调节细胞的免疫抑制活性。加地喹莫特可作为诺沃克病毒样颗粒的粘膜佐剂有效，并抑制HIV-1对巨噬细胞和T细胞的感染。它抑制增殖和迁移，同时在体外诱导胰腺癌细胞凋亡。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK15601-5mg	5mg	>98%	¥ 3080.00	¥ 3080.00		2 Weeks	- +	¥ 0.00

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中文别名	1020412-43-4;加地喹莫德;Toll 样受体7（TLR7）激动剂;Toll 样受体7激动剂;TLR7激动剂;
英文别名	Gardiquimod;toll-like receptor 7 (TLR7) agonist;toll-like receptor agonist;TLR7 agonist ;
CAS号	1020412-43-4
Inchi	InChI=1S/C17H23N5O/c1-4-19-9-13-21-14-15(22(13)10-17(2,3)23)11-7-5-6-8-12(11)20-16(14)18/h5-8,19,23H,4,9-10H2,1-3H3,(H2,18,20)
InchiKey	FHJATBIERQTCTN-UHFFFAOYSA-N
分子式 Formula	C17H23N5O
分子量 Molecular Weight	313.4
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	加地喹莫特是人类toll样受体7（TLR7）的激动剂，但不是人类TLR8，尽管它同时激活猪TLR7和TLR8。在0.5至2μg/ ml时，它增强了T调节细胞的免疫抑制活性。加地喹莫特可作为诺沃克病毒样颗粒的粘膜佐剂有效，并抑制HIV-1对巨噬细胞和T细胞的感染。它抑制增殖和迁移，同时在体外诱导胰腺癌细胞凋亡。
Introduction	Gardiquimod is an agonist of human toll-like receptor 7 (TLR7), but not human TLR8, although it activates both porcine TLR7 and TLR8.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kim S, Kaiser P, Borowska D, Vervelde L. Synergistic effect of co-stimulation of membrane and endosomal TLRs on chicken innate immune responses. Vet Immunol Immunopathol. 2018 May;199:15-2[1]doi: 10.1016/j.vetimm.2018.03.005. Epub 2018 Mar 19. PubMed PMID: 29678225.

[2]Enosi Tuipulotu D, Netzler NE, Lun JH, Mackenzie JM, White PA. TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02417-17. doi: 10.1128/AAC.02417-17. Print 2018 May. PubMed PMID: 29530841; PubMed Central PMCID: PMC5923118.

[3] Rudra JS, Banasik BN, Milligan GN. A combined carrier-adjuvant system of peptide nanofibers and toll-like receptor agonists potentiates robust CD8+ T cell responses. Vaccine. 2018 Jan 25;36(4):438-441. doi: 10.1016/j.vaccine.2017.12.017. Epub 2017 Dec 14. PubMed PMID: 29248267; PubMed Central PMCID: PMC5769694.

[4] Braun RO, Python S, Summerfield A. Porcine B Cell Subset Responses to Toll-like Receptor Ligands. Front Immunol. 2017 Aug 25;8:1044. doi: 10.3389/fimmu.2017.01044. eCollection 2017. PubMed PMID: 28890720; PubMed Central PMCID: PMC5574874.

[5] Chi H, Li C, Zhao FS, Zhang L, Ng TB, Jin G, Sha O. Anti-tumor Activity of Toll-Like Receptor 7 Agonists. Front Pharmacol. 2017 May 31;8:304. doi: 10.3389/fphar.2017.00304. eCollection 2017. Review. PubMed PMID: 28620298; PubMed Central PMCID: PMC5450331.

6: Zhu Q, Kanneganti TD. Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β. J Immunol. 2017 Jun 1;198(11):4210-4215. doi: 10.4049/jimmunol.1700352. Epub 2017 May 3. PubMed PMID: 28468974; PubMed Central PMCID: PMC5544497.7: Guo S, Zhang Y, Wang Z, Yu Y, Wang G. Intraperitoneal gardiquimod protects against hepatotoxicity through inhibition of oxidative stress and inflammation in mice with sepsis. J Biochem Mol Toxicol. 2017 Aug;31(8). doi: 10.1002/jbt.21923. Epub 2017 Apr 19. PubMed PMID: 28422377.8: Seth A, Lee H, Cho MY, Park C, Korm S, Lee JY, Choi I, Lim YT, Hong KS. Combining vasculature disrupting agent and Toll-like receptor 7/8 agonist for cancer therapy. Oncotarget. 2017 Jan 17;8(3):5371-5381. doi: 10.18632/oncotarget.14260. PubMed PMID: 28036266; PubMed Central PMCID: PMC5354915.9: Gupta N, Vedi S, Kunimoto DY, Agrawal B, Kumar R. Novel lipopeptides of ESAT-6 induce strong protective immunity against Mycobacterium tuberculosis: Routes of immunization and TLR agonists critically impact vaccine's efficacy. Vaccine. 2016 Nov 4;34(46):5677-5688. doi: 10.1016/j.vaccine.2016.08.075. Epub 2016 Sep 29. PubMed PMID: 27693020.10: Liu Y, Guo X, Wu L, Yang M, Li Z, Gao Y, Liu S, Zhou G, Zhao J. Lipid rafts promote liver cancer cell proliferation and migration by up-regulation of TLR7 expression. Oncotarget. 2016 Sep 27;7(39):63856-63869. doi: 10.18632/oncotarget.11697. PubMed PMID: 27588480; PubMed Central PMCID: PMC5325409.1

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