106518-61-0|Ganoderiol A|(3S,6R)-6-((3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptane-1,2,3-triol|-范德生物科技公司

Ganoderiol A

NMR下载 COA and HPLC MSDS下载
names：
(3S,6R)-6-((3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptane-1,2,3-triol
CAS号：
106518-61-0
MDL Number：
MF(分子式)： C30H50O4 MW(分子量)： 474.72
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Ganoderiol A
英文别名	Ganoderiol A; Ganoderiol A, (+)-; (+)-Ganoderiol A;
CAS号	106518-61-0
SMILES	CC1(C)[C@@H](O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC[C@H](O)C(C)(O)CO)CC[C@](C)4C3=CC[C@@]12[H]
Inchi	InChI=1S/C30H50O4/c1-19(8-11-25(33)30(7,34)18-31)20-12-16-29(6)22-9-10-23-26(2,3)24(32)14-15-27(23,4)21(22)13-17-28(20,29)5/h9,13,19-20,23-25,31-34H,8,10-12,14-18H2,1-7H3/t19-,20-,23+,24+,25+,27-,28-,29+,30?/m1/s1
InchiKey	VMEFPSOTFFVAQJ-OBGNTNONSA-N
分子式 Formula	C30H50O4
分子量 Molecular Weight	474.72
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ganoderiol A(CAS:106518-61-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ganoderiol A is a tetracyclic triterpene isolated from Ganoderma amboinense.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT. Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS One. 2013 Oct 29;8(10):e76620. doi: 10.1371/journal.pone.0076620. eCollection 2013. PubMed PMID: 24204647; PubMed Central PMCID: PMC3812178.

[2]Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB. Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells. Life Sci. 2006 Aug 15;79(12):1129-39. Epub 2006 Mar 28. PubMed PMID: 16635496.

[3] Liu JQ, Wang CF, Li Y, Luo HR, Qiu MH. Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense. Planta Med. 2012 Mar;78(4):368-76. doi: 10.1055/s-0031-1280441. Epub 2011 Dec 12. PubMed PMID: 22161763.

[4] Zhang Q, Zuo F, Nakamura N, Ma CM, Hattori M. Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. J Nat Med. 2009 Jul;63(3):304-10. doi: 10.1007/s11418-009-0337-5. Epub 2009 May 1. PubMed PMID: 19407927.

[5] el-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7. PubMed PMID: 9862140.

6: Sato N, Ma CM, Komatsu K, Hattori M. Triterpene-farnesyl hydroquinone conjugates from Ganoderma sinense. J Nat Prod. 2009 May 22;72(5):958-61. doi: 10.1021/np800687t. PubMed PMID: 19331378.7: Choi S, Nguyen VT, Tae N, Lee S, Ryoo S, Min BS, Lee JH. Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42. doi: 10.1016/j.taap.2014.09.007. Epub 2014 Sep 16. PubMed PMID: 25239868.8: Qiao Y, Zhang XM, Qiu MH. Two novel lanostane triterpenoids from Ganoderma sinense. Molecules. 2007 Aug 23;12(8):2038-46. PubMed PMID: 17960104.9: Grienke U, Mihály-Bison J, Schuster D, Afonyushkin T, Binder M, Guan SH, Cheng CR, Wolber G, Stuppner H, Guo DA, Bochkov VN, Rollinger JM. Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum. Bioorg Med Chem. 2011 Nov 15;19(22):6779-91. doi: 10.1016/j.bmc.2011.09.039. Epub 2011 Sep 29. PubMed PMID: 22014750; PubMed Central PMCID: PMC3254236.10: Zhang SS, Ma QY, Huang SZ, Dai HF, Guo ZK, Yu ZF, Zhao YX. Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes. Phytochemistry. 2015 Feb;110:133-9. doi: 10.1016/j.phytochem.2014.12.012. Epub 2015 Jan 7. PubMed PMID: 25577284.1

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