101706-33-6|FR 900452|1-methyl-3-[1-[5-(methylsulfanylmethyl)-6-oxo-3-(2-oxocyclopent-3-en-1-ylidene)piperazin-2-yl]ethyl]-3H-indol-2-one|-范德生物科技公司

FR 900452

NMR下载 COA and HPLC MSDS下载
names：
1-methyl-3-[1-[5-(methylsulfanylmethyl)-6-oxo-3-(2-oxocyclopent-3-en-1-ylidene)piperazin-2-yl]ethyl]-3H-indol-2-one
CAS号：
101706-33-6
MDL Number：
MF(分子式)： C22H25N3O3S MW(分子量)： 411.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	FR 900452
英文别名	FR 900452; FR900452; FR-900452
CAS号	101706-33-6
SMILES	O=C1N(C)C2=C(C=CC=C2)C1C(C(/C(NC3CSC)=C4C(C=CC/4)=O)NC3=O)C
Inchi	InChI=1S/C22H25N3O3S/c1-12(18-13-7-4-5-9-16(13)25(2)22(18)28)19-20(14-8-6-10-17(14)26)23-15(11-29-3)21(27)24-19/h4-7,9-10,12,15,18-19,23H,8,11H2,1-3H3,(H,24,27)/b20-14-
InchiKey	UAPDNDKYPBHNQT-ZHZULCJRSA-N
分子式 Formula	C22H25N3O3S
分子量 Molecular Weight	411.52
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	FR 900452(CAS:101706-33-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	FR 900452 is a platelet activating factor antagonist from fermentatiion products of Streptomyces phaeofaciens.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Komaki H, Ichikawa N, Hosoyama A, Fujita N, Igarashi Y. Draft Genome Sequence of Streptomyces sp. TP-A0890, a Producer of FR-900452 and A-74863a. Genome Announc. 2015 Oct 15;3(5). pii: e01212-15. doi: 10.1128/genomeA.01212-15. PubMed PMID: 26472848; PubMed Central PMCID: PMC4611700.

[2]Okamoto M, Yoshida K, Nishikawa M, Ando T, Iwami M, Kohsaka M, Aoki H. FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1986 Feb;39(2):198-204. PubMed PMID: 3082838.

[3] Okamoto M, Yoshida K, Nishikawa M, Kohsaka M, Aoki H. Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. Thromb Res. 1986 Jun 1;42(5):661-71. PubMed PMID: 3754990.

[4] Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

[5] Okamoto M, Yoshida K, Nishikawa M, Hayashi K, Uchida I, Kohsaka M, Aoki H. Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. Chem Pharm Bull (Tokyo). 1986 Jul;34(7):3005-10. PubMed PMID: 3769104.

6: Hu W, McNicholl IK, Choy PC, Man RY. Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart. Br J Pharmacol. 1993 Oct;110(2):645-50. PubMed PMID: 8242237; PubMed Central PMCID: PMC2175904.7: Suzuki S, Nozawa R, Suzuki J, Kato K, Suzuki H, Sakurai K. [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. Nihon Jinzo Gakkai Shi. 1988 Aug;30(8):985-90. Japanese. PubMed PMID: 3244194.8: Hu W, Kinnaird AA, Man RY. Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 May;103(1):1097-102. PubMed PMID: 1652337; PubMed Central PMCID: PMC1908074.9: Man RY, Kinnaird AA. Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties. Br J Pharmacol. 1995 Nov;116(5):2359-64. PubMed PMID: 8581269; PubMed Central PMCID: PMC1909066.10: Chan WP, Levy JV. Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. Prostaglandins. 1991 Oct;42(4):337-42. PubMed PMID: 1665568.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开