62874-51-5|Fortimicin C|N-((1S,2R,3R,4S,5S,6R)-4-amino-3-(((2R,3R,6S)-3-amino-6-((S)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxy-6-methoxycyclohexyl)-N-methyl-2-ureidoacetamide|-范德生物科技公司

Fortimicin C

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names：
N-((1S,2R,3R,4S,5S,6R)-4-amino-3-(((2R,3R,6S)-3-amino-6-((S)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxy-6-methoxycyclohexyl)-N-methyl-2-ureidoacetamide
CAS号：
62874-51-5
MDL Number：
MF(分子式)： C18H36N6O7 MW(分子量)： 448.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Fortimicin C
英文别名	Fortimicin C;
CAS号	62874-51-5
Inchi	InChI=1S/C18H36N6O7/c1-7(19)9-5-4-8(20)17(30-9)31-15-11(21)13(26)16(29-3)12(14(15)27)24(2)10(25)6-23-18(22)28/h7-9,11-17,26-27H,4-6,19-21H2,1-3H3,(H3,22,23,28)/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1
InchiKey	VKGIGFQBOYWLHV-APGVDKLISA-N
分子式 Formula	C18H36N6O7
分子量 Molecular Weight	448.52
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Fortimicin C(CAS:62874-51-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Fortimicin C is a bioactive chemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Huong NL, Hoang NH, Hong SY, Sohng JK, Yoon YJ, Park JW. Characterization of fortimicin aminoglycoside profiles produced from Micromonospora olivasterospora DSM 43868 by high-performance liquid chromatography-electrospray ionization-ion trap-mass spectrometry. Anal Bioanal Chem. 2016 Feb;408(6):1667-78. doi: 10.1007/s00216-015-9281-2. Epub 2016 Jan 1[1]PubMed PMID: 26753981.

[2]Galimand M, Courvalin P, Lambert T. RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family. Antimicrob Agents Chemother. 2012 Jul;56(7):3960-2. doi: 10.1128/AAC.00660-12. Epub 2012 Apr 30. PubMed PMID: 22547620; PubMed Central PMCID: PMC3393463.

[3] Hasegawa M. A novel, highly efficient gene-cloning system in Micromonospora applied to the genetic analysis of fortimicin biosynthesis. Gene. 1992 Jun 15;115(1-2):85-91. PubMed PMID: 1612453.

[4] Dairi T, Hasegawa M. Common biosynthetic feature of fortimicin-group antibiotics. J Antibiot (Tokyo). 1989 Jun;42(6):934-43. PubMed PMID: 2737953.

[5] Hotta K, Morioka M, Okami Y. Biosynthetic similarity between Streptomyces tenjimariensis and Micromonospora olivasterospora which produce fortimicin-group antibiotics. J Antibiot (Tokyo). 1989 May;42(5):745-51. PubMed PMID: 2722689.

6: Stefani S, Debbia EA, Schito GC, Russo G. Microbiological characterization of dactimicin: antibacterial activity towards gram-positive and gram-negative bacteria. Drugs Exp Clin Res. 1989;15(3):119-23. PubMed PMID: 2752910.7: Price KE. The potential for discovery and development of improved aminoglycosides. Am J Med. 1986 Jun 30;80(6B):182-9. Review. PubMed PMID: 3089002.8: Moreau N, Jaxel C, Le Goffic F. Comparison of fortimicins with other aminoglycosides and effects on bacterial ribosome and protein synthesis. Antimicrob Agents Chemother. 1984 Dec;26(6):857-62. PubMed PMID: 6395800; PubMed Central PMCID: PMC180039.9: Tadanier J, Hallas R. 3-O-demethyl-2,3-di-epi-fortimicins and 3-O-demethyl-3-epi-fortimicins. J Antibiot (Tokyo). 1983 Mar;36(3):256-66. PubMed PMID: 6833145.10: Hirayama N, Shirahata K, Ohashi Y, Sasada Y. Conformations of fortimicins and three-dimensional structure-activity relationship in the aminoglycoside antibiotics. Mol Pharmacol. 1983 Jan;23(1):127-32. PubMed PMID: 6865896.1

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