154540-49-5|Fluoroclebopride|4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methoxybenzamide|-范德生物科技公司

Fluoroclebopride

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names：
4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methoxybenzamide
CAS号：
154540-49-5
MDL Number：
MF(分子式)： C20H23ClFN3O2 MW(分子量)： 391.8714
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Fluoroclebopride
英文别名	Fluoroclebopride
CAS号	154540-49-5
Inchi	InChI=1S/C20H23ClFN3O2/c1-27-19-11-18(23)17(21)10-16(19)20(26)24-15-6-8-25(9-7-15)12-13-2-4-14(22)5-3-13/h2-5,10-11,15H,6-9,12,23H2,1H3,(H,24,26)
InchiKey	HKDIGEWWDHALIS-UHFFFAOYSA-N
分子式 Formula	C20H23ClFN3O2
分子量 Molecular Weight	391.8714
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Fluoroclebopride(CAS:154540-49-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Fluoroclebopride is useful chemical for PET image study. [18F]fluoroclebopride had been used for PET imaging of dopamine D2 receptors in monkeys.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Czoty PW, Gage HD, Garg PK, Garg S, Nader MA. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29. [Epub ahead of print] PubMed PMID: 24077804; PubMed Central PMCID: PMC3969775.

[2]Gill KE, Pierre PJ, Daunais J, Bennett AJ, Martelle S, Gage HD, Swanson JM, Nader MA, Porrino LJ. Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates. Neuropsychopharmacology. 2012 Nov;37(12):2555-65. doi: 10.1038/npp.2012.117. Epub 2012 Jul 18. PubMed PMID: 22805600; PubMed Central PMCID: PMC3473324.

[3] Hamilton LR, Czoty PW, Gage HD, Nader MA. Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation. Psychopharmacology (Berl). 2010 Jul;210(4):481-8. doi: 10.1007/s00213-010-1847-2. Epub 2010 Apr 20. PubMed PMID: 20401746; PubMed Central PMCID: PMC2878372.

[4] Czoty PW, Gage HD, Nader MA. Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine. Psychopharmacology (Berl). 2010 Mar;208(4):585-92. doi: 10.1007/s00213-009-1756-4. PubMed PMID: 20066401; PubMed Central PMCID: PMC2891780.

[5] Czoty PW, Riddick NV, Gage HD, Sandridge M, Nader SH, Garg S, Bounds M, Garg PK, Nader MA. Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys. Neuropsychopharmacology. 2009 Feb;34(3):548-54. doi: 10.1038/npp.2008.3. Epub 2008 Feb 6. PubMed PMID: 18256593.

6: Czoty PW, Gage HD, Nader SH, Reboussin BA, Bounds M, Nader MA. PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys. J Addict Med. 2007 Mar;1(1):33-9. doi: 10.1097/ADM.0b013e318045c038. PubMed PMID: 21768930.7: Czoty PW, Gage HD, Nader MA. PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatment. Synapse. 2005 Dec 15;58(4):215-9. PubMed PMID: 16206180.8: Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162(8):1473-82. Review. PubMed PMID: 16055768.9: Fahey FH, Gage HD, Buchheimer N, Smith HC, Harkness BA, Williams RC, Bounds MC, Mercier J, Robbins ME, Payne RM, Morton KA, Mach RH. Evaluation of the quantitative capability of a high-resolution positron emission tomography scanner for small animal imaging. J Comput Assist Tomogr. 2004 Nov-Dec;28(6):842-8. PubMed PMID: 15538162.10: Czoty PW, Morgan D, Shannon EE, Gage HD, Nader MA. Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine. Psychopharmacology (Berl). 2004 Jul;174(3):381-8. Epub 2004 Feb 7. PubMed PMID: 14767632.1

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