66934-18-7|Flunoxaprofen|2-(2-(4-fluorophenyl)benzo[d]oxazol-5-yl)propanoic acid|-范德生物科技公司

Flunoxaprofen

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names：
2-(2-(4-fluorophenyl)benzo[d]oxazol-5-yl)propanoic acid
CAS号：
66934-18-7
MDL Number：
MF(分子式)： C16H12FNO3 MW(分子量)： 285.27
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Flunoxaprofen
英文别名	Flunoxaprofen; Priaxim; RV-12424; RV 12424; RV12424;
CAS号	66934-18-7
Inchi	InChI=1S/C16H12FNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20)
InchiKey	ARPYQKTVRGFPIS-UHFFFAOYSA-N
分子式 Formula	C16H12FNO3
分子量 Molecular Weight	285.27
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Flunoxaprofen(CAS:66934-18-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Flunoxaprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) that is closely related to naproxen. Flunoxaprofen has been shown to significantly improve the symptoms of osteoarthritis and rheumatoid arthritis.
Application1
Application2
Application3

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危险性	Warning
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备注

[1]Furlanut M, Montanari G, Perosa A, Velussi C, Forgione A, Palatini P. Absorption and disposition kinetics of flunoxaprofen and benoxaprofen in healthy volunteers. Int J Clin Pharmacol Res. 1985;5(3):165-70. PubMed PMID: 4018949.

[2]Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metab Dispos. 2010 Jan;38(1):133-42. doi: 10.1124/dmd.109.029371. PubMed PMID: 19786506; PubMed Central PMCID: PMC2802421.

[3] Cecchini G, Ferutta P, Soldà A, Ragazzi G. [Non-specific vaginitis and topical treatment. Comparison of flunoxaprofen and benzydamine]. Minerva Ginecol. 1989 Jun;41(6):287-90. Italian. PubMed PMID: 2671808.

[4] Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug Metab Dispos. 1991 Sep-Oct;19(5):853-7. PubMed PMID: 1686227.

[5] Fioravanti A, Giordano N, Megale F, Jovane D, Franci A, Marcolongo R. [Efficacy and tolerability of flunoxaprofen in the treatment of rheumatoid arthritis. A cross-over clinical study using naproxen]. Clin Ter. 1989 Oct 31;131(2):83-91. Italian. PubMed PMID: 2533024.

6: Dahms M, Spahn-Langguth H. Covalent binding of acidic drugs via reactive intermediates: detection of benoxaprofen and flunoxaprofen protein adducts in biological material. Pharmazie. 1996 Nov;51(11):874-81. PubMed PMID: 8985978.7: Facchini V, Rispoli G, Dubini F, Bignami P, Sacchi C. [Activity of topical flunoxaprofen in nonspecific vaginitis. Comparison with meclocycline sulfosalicylate]. Minerva Ginecol. 1989 Dec;41(12):609-14. Italian. PubMed PMID: 2626206.8: Dong JQ, Smith PC. Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes. Drug Metab Dispos. 2009 Dec;37(12):2314-22. doi: 10.1124/dmd.109.028944. Epub 2009 Sep 22. PubMed PMID: 19773537; PubMed Central PMCID: PMC2784705.9: Pedrazzini S, De Angelis M, Muciaccia WZ, Sacchi C, Forgione A. Stereochemical pharmacokinetics of the 2-arylpropionic acid non-steroidal antiinflammatory drug flunoxaprofen in rats and in man. Arzneimittelforschung. 1988 Aug;38(8):1170-5. PubMed PMID: 3196413.10: Dong JQ, Liu J, Smith PC. Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo. Biochem Pharmacol. 2005 Sep 15;70(6):937-48. PubMed PMID: 16046212.1

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