211735-76-1|Farampator|1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine|-范德生物科技公司

Farampator

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names：
1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine
CAS号：
211735-76-1
MDL Number：
MF(分子式)： C12H13N3O2 MW(分子量)： 231.255
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Farampator
英文别名	Farampator; Org-24448; CX-691; Org24448; CX691.
CAS号	211735-76-1
Inchi	InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2
InchiKey	XFVRBYKKGGDPAJ-UHFFFAOYSA-N
分子式 Formula	C12H13N3O2
分子量 Molecular Weight	231.255
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Farampator(CAS:211735-76-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Farampator, also known as Org-24448; CX-691, is an AMPA receptor positive allosteric modulator potentially for the treatment of schizophrenia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
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备注

[1]Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH. Differentialeffects of AMPA receptor potentiators and glycine reuptake inhibitors onantipsychotic efficacy and prefrontal glutamatergic transmission.Psychopharmacology (Berl). 2012 May;221(1):115-3[1]doi:10.1007/s00213-011-2554-3. PubMed PMID: 22068461.

[2]Woolley ML, Waters KA, Gartlon JE, Lacroix LP, Jennings C, Shaughnessy F, OngA, Pemberton DJ, Harries MH, Southam E, Jones DN, Dawson LA. Evaluation of thepro-cognitive effects of the AMPA receptor positive modulator,5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. doi:10.1007/s00213-008-1325-2. PubMed PMID: 18795266.

[3] Dawson N, Ferrington L, Olverman HJ, Kelly PA. Novel analysis for improvedvalidity in semi-quantitative 2-deoxyglucose autoradiographic imaging. J NeurosciMethods. 2008 Oct 30;175(1):25-35. doi: 10.1016/j.jneumeth.2008.07.020. PubMedPMID: 18762213.

[4] Wezenberg E, Verkes RJ, Ruigt GS, Hulstijn W, Sabbe BG. Acute effects of theampakine farampator on memory and information processing in healthy elderlyvolunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83. PubMed PMID:17119538.

[5] Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K. Regionallyselective and dose-dependent effects of the ampakines Org 26576 and Org 24448 onlocal cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucoseautoradiography. Neuropharmacology. 2005 Aug;49(2):254-64. PubMed PMID: 15993447.

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