
-
F 522
- names:
2-(dimethylamino)ethyl methacrylate compound with ethene (11)
- CAS号:
25134-54-7
MDL Number: - MF(分子式): C10H19NO2 MW(分子量): 185.27
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
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中文别名 | F 522 |
英文别名 | F 522; DA 1701; DA 3023; DA 3031;F522; F-522; Sumiepoch F 522; |
CAS号 | 25134-54-7 |
SMILES | C(C(=C)C)(=O)OCCN(C)C.C=C |
Inchi | InChI=1S/C8H15NO2.C2H4/c1-7(2)8(10)11-6-5-9(3)4;1-2/h1,5-6H2,2-4H3;1-2H2 |
InchiKey | PNMYDOBPCBCQIA-UHFFFAOYSA-N |
分子式 Formula | C10H19NO2 |
分子量 Molecular Weight | 185.27 |
闪点 FP | |
熔点 Melting point | |
沸点 Boiling point | |
Polarizability极化度 | |
密度 Density | |
蒸汽压 Vapor Pressure | |
溶解度Solubility | |
性状 | Solid powder |
储藏条件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
产品说明 | F 522(CAS:25134-54-7):仅限应用于工业或者科学研究过程中非医疗目的,不应用于人类或动物的临床诊断以及治过程疗,该产品非药用,非食用。 |
Introduction | F 522 is also kown as DA-3031. DA-3031 is a newly developed pegylated filgrastim, a recombinant human granulocyte colony-stimulating factor, that is expected to have an extended duration of action compared with non-modified filgrastim. was developed for prophylactic use in breast cancer. |
Application1 | |
Application2 | |
Application3 |
[1]Ahn LY, Shin KH, Lim KS, Kim TE, Jeon H, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS. Relationship between absolute neutrophil count profiles and pharmacokinetics of DA-3031, a pegylated granulocyte colony-stimulating factor (pegylated-G-CSF): a dose block-randomized, double-blind, dose-escalation study in healthy subjects. Clin Drug Investig. 2013 Nov;33(11):817-24. PubMed PMID: 24078278. |
[2]Park KH, Sohn JH, Lee S, Park JH, Kang SY, Kim HY, Park IH, Park YH, Im YH, Lee HJ, Hong DS, Park S, Shin SH, Kwon HC, Seo JH. A randomized, multi-center, open-label, phase II study of once-per-cycle DA-3031, a biosimilar pegylated G-CSF, compared with daily filgrastim in patients receiving TAC chemotherapy for early-stage breast cancer. Invest New Drugs. 2013 Oct;31(5):1300-6. doi: 10.1007/s10637-013-9973-4. Epub 2013 May 16. PubMed PMID: 23677653. |
[3] Wadhwa M, Bird C, Dougall T, Rigsby P, Bristow A, Thorpe R; participants of the study. Establishment of the first international standard for PEGylated granulocyte colony stimulating factor (PEG-G-CSF): report of an international collaborative study. J Immunol Methods. 2015 Jan;41 |
6:17-28. doi: 10.1016/j.jim.2014.10.005. Epub 2014 Oct 25. PubMed PMID: 25450254; PubMed Central PMCID: PMC4334095. |
[5] Park KH, Lee S, Park JH, Kang SY, Kim HY, Park IH, Park YH, Im YH, Lee HJ, Park S, Lee SI, Jung KH, Kim YS, Seo JH. A randomized, multi-center, open-label, phase III study of once-per-cycle DA-3031, a pegylated G-CSF, in comparison with daily filgrastim in patients receiving TAC chemotherapy for breast cancer. Support Care Cancer. 2017 Feb;25(2):505-511. doi: 10.1007/s00520-016-3429-2. Epub 2016 Oct 6. PubMed PMID: 27709313. |
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