145512-85-2|Eprociclovir|2-amino-9-{[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl}-1,9-dihydro-6H-purin-6-one|-范德生物科技公司

Eprociclovir

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names：
2-amino-9-{[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl}-1,9-dihydro-6H-purin-6-one
CAS号：
145512-85-2
MDL Number：
MF(分子式)： C11H15N5O3 MW(分子量)： 265.273
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK15019-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Eprociclovir
英文别名	A-5021; A5021; A 5021; AV-10; AV10; AV 10; Eprociclovir;
CAS号	145512-85-2
Inchi	InChI=1S/C11H15N5O3/c12-10-14-8-7(9(19)15-10)13-5-16(8)3-11(4-18)1-6(11)2-17/h5-6,17-18H,1-4H2,(H3,12,14,15,19)/t6-,11-/m0/s1
InchiKey	JLYSZBQNRJVPEP-KGFZYKRKSA-N
分子式 Formula	C11H15N5O3
分子量 Molecular Weight	265.273
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Eprociclovir(CAS:145512-85-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Eprociclovir, also known as A-5021, is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Glorieux S, Vandekerckhove AP, Goris N, Yang XY, Steukers L, Van de Walle GR, Croubels S, Neyts J, Nauwynck HJ. Evaluation of the antiviral activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) against equine herpesvirus type 1 in cell monolayers and equine nasal mucosal explants. Antiviral Res. 2012 Feb;93(2):234-8. doi: 10.1016/j.antiviral.2011.11.016. Epub 2011 Dec 8. PubMed PMID: 22178244.

[2]Ostrowski T, Golankiewicz B, De Clercq E, Andrei G, Snoeck R. Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues. Eur J Med Chem. 2009 Aug;44(8):3313-7. doi: 10.1016/j.ejmech.2009.03.005. Epub 2009 Mar 21. PubMed PMID: 19339082.

[3] Itahashi M, Higaki S, Sugahara D, Sugioka K, Deai T, Takao K, Hayashi K, Shimomura Y. A-502

[4]a new acyclovir analogue inhibits murine herpetic keratitis. Cornea. 2008 Apr;27(3):334-8. doi: 10.1097/ICO.0b013e31815d889b. PubMed PMID: 18362663.

[5] De Clercq E, Naesens L. In search of effective anti-HHV-6 agents. J Clin Virol. 2006 Dec;37 Suppl [5]S82-6. Review. PubMed PMID: 17276375.

5: Golankiewicz B, Ostrowski T. Tricyclic nucleoside analogues as antiherpes agents. Antiviral Res. 2006 Sep;71(2-3):134-40. Epub 2006 May 30. Review. PubMed PMID: 16780965.

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