68576-86-3|Enciprazine|1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(3,4,5-trimethoxyphenoxy)propan-2-ol|-范德生物科技公司

Enciprazine

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names：
1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(3,4,5-trimethoxyphenoxy)propan-2-ol
CAS号：
68576-86-3
MDL Number：
MF(分子式)： C23H32N2O6 MW(分子量)： 432.517
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Enciprazine
英文别名	D-3112; D 3112; D3112; WY-48624; WY48624; WY 48624; Enciprazine.
CAS号	68576-86-3
Inchi	InChI=1S/C23H32N2O6/c1-27-20-8-6-5-7-19(20)25-11-9-24(10-12-25)15-17(26)16-31-18-13-21(28-2)23(30-4)22(14-18)29-3/h5-8,13-14,17,26H,9-12,15-16H2,1-4H3
InchiKey	KSQCNASWXSCJTD-UHFFFAOYSA-N
分子式 Formula	C23H32N2O6
分子量 Molecular Weight	432.517
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Enciprazine(CAS:68576-86-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Enciprazine, also known as D-3112; WY-48624, is a GABA receptor agonist potentially for the treatment of anxiety disorders.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Matheson GK, Knowles A, Gage D, Michel C, Guthrie D, Bauer C, Blackbourne J, Weinzapfel D. Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat. Pharmacology. 1997 Aug;55(2):59-65. PubMed PMID: 9323305.

[2]Scatina JA, Lockhead SR, Cayen MN, Sisenwine SF. Metabolic disposition of enciprazine, a non-benzodiazepine anxiolytic drug, in rat, dog and man. Xenobiotica. 1991 Dec;21(12):1591-604. PubMed PMID: 1686125.

[3] Engel J, Fleischhauer I, Jakovlev V, Kleemann A, Kutscher B, Nickel B, Rauer H, Werner U, Szelenyi I, Johanson CE, et al. Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. J Med Chem. 1990 Nov;33(11):2976-81. PubMed PMID: 1977910.

[4] Scheibe G, Grohmann R, Buchheim P. Pilot study on the therapeutic efficacy, clinical safety, and dosage finding of enciprazine in out-patients with anxious and anxious-depressive syndromes. Arzneimittelforschung. 1990 Jun;40(6):644-6. PubMed PMID: 2204343.

[5] Schweizer E, Rickels K, Csanalosi I, London J, Turner D. A placebo-controlled study of enciprazine in the treatment of generalized anxiety disorder: a preliminary report. Psychopharmacol Bull. 1990;26(2):215-7. PubMed PMID: 2236459.

6: Nickel B, Szelenyi I. Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology. 1989 Aug;28(8):799-803. PubMed PMID: 2571102.7: Linden M, Helmchen H, Müller-Oerlinghausen B. Early phase-II semi double-blind study of the new alkaline propanolamine derivative enciprazine (short communication). Arzneimittelforschung. 1988 Jun;38(6):814-6. PubMed PMID: 3178922.

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