68284-69-5|Disobutamide|1-Piperidinebutanamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-(2-chlorophenyl)-|-范德生物科技公司

Disobutamide

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names：
1-Piperidinebutanamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-(2-chlorophenyl)-
CAS号：
68284-69-5
MDL Number：
MF(分子式)： C23H38ClN3O MW(分子量)： 408.03
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Disobutamide
英文别名	Disobutamide
CAS号	68284-69-5
Inchi	InChI=1S/C23H38ClN3O/c1-18(2)27(19(3)4)17-13-23(22(25)28,20-10-6-7-11-21(20)24)12-16-26-14-8-5-9-15-26/h6-7,10-11,18-19H,5,8-9,12-17H2,1-4H3,(H2,25,28)
InchiKey	YKFWMDHZMQLWBO-UHFFFAOYSA-N
分子式 Formula	C23H38ClN3O
分子量 Molecular Weight	408.03
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Disobutamide(CAS:68284-69-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Disobutamide is a Cardiac Depressant (Anti-Arrhythmic).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ruben Z, Fuller GC, Knodle SG. Disobutamide-induced cytoplasmic vacuoles in cultured dog coronary artery muscle cells. Arch Toxicol. 1984 Sep;55(3):206-12. PubMed PMID: 6497655.

[2]Hjelle JT, Ruben Z. Investigations in intracellular drug storage: localization of disobutamide in lysosomal and nonlysosomal vesicles. Toxicol Appl Pharmacol. 1989 Oct;101(1):70-82. PubMed PMID: 2799819.

[3] Ruben Z, Dodd DC, Rorig KJ, Anderson SN. Disobutamide: a model agent for investigating intracellular drug storage. Toxicol Appl Pharmacol. 1989 Jan;97(1):57-71. PubMed PMID: 2464862.

[4] Dresel PE, Cameron KD. Effect of disopyramide and disobutamide on conduction in perfused rabbit hearts. Can J Physiol Pharmacol. 1981 Nov;59(11):1192-5. PubMed PMID: 7317843.

[5] Ruben Z, Anderson SN, Rorig KJ, Hribar JD, Bible RH Jr. The pH dependence of disobutamide-induced clear cytoplasmic vacuoles in cultured cells. Proc Soc Exp Biol Med. 1985 Oct;180(1):84-91. PubMed PMID: 4034538.

6: Desai BN, Fowler KW, Chorvat RJ, Frederick LG, Hatley FR, Rorig KJ, Garthwaite SM. Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: monobasic derivatives of disobutamide. J Med Chem. 1988 Nov;31(11):2158-64. PubMed PMID: 2846841.7: Ruben Z, Anderson SN, Fuller GC. The susceptibility of various cultured cells to induction of clear cytoplasmic vacuoles by disobutamide. Toxicol In Vitro. 1990;4(4-5):497-505. PubMed PMID: 20702220.8: Cook CS, McDonald SJ, Karim A. Importance of pharmacokinetic and physicochemical data in the discovery and development of novel anti-arrhythmic drugs. Xenobiotica. 1993 Nov;23(11):1299-309. PubMed PMID: 8310713.9: Koizumi H, Watanabe M, Numata H, Sakai T, Morishita H. Species differences in vacuolation of the choroid plexus induced by the piperidine-ring drug disobutamide in the rat, dog, and monkey. Toxicol Appl Pharmacol. 1986 Jun 15;84(1):125-48. PubMed PMID: 3715860.10: Dohrmann ML, Harrell FE Jr, Strauss HC. The effects of disobutamide on electrophysiologic properties of canine cardiac Purkinje fibers and papillary muscle. J Pharmacol Exp Ther. 1981 Jun;217(3):549-54. PubMed PMID: 7229991.1

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