127943-53-7|Disermolide|2H-Pyran-2-one, 6-(14-((aminocarbonyl)oxy)-2,6,12-trihydroxy-5,7,9,11,13,15-hexamethyl-3,8,16,18-nonadecatetraenyl)tetrahydro-4-hydroxy-3,5-dimethyl-, (3S-(3alpha,4beta,5beta,6alpha(2R*,3Z,5R*,6R*,7S*,8Z,11R*,12S*,13S*,14S*,15R*,16E)))-|-范德生物科技公司

Disermolide

NMR下载 COA and HPLC MSDS下载
names：
2H-Pyran-2-one, 6-(14-((aminocarbonyl)oxy)-2,6,12-trihydroxy-5,7,9,11,13,15-hexamethyl-3,8,16,18-nonadecatetraenyl)tetrahydro-4-hydroxy-3,5-dimethyl-, (3S-(3alpha,4beta,5beta,6alpha(2R*,3Z,5R*,6R*,7S*,8Z,11R*,12S*,13S*,14S*,15R*,16E)))-
CAS号：
127943-53-7
MDL Number：
MF(分子式)： C33H55NO8 MW(分子量)： 593.802
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Disermolide
英文别名	Disermolide; XAA 296; XAA-296; XAA296.
CAS号	127943-53-7
Inchi	InChI=1S/C33H55NO8/c1-10-11-12-20(4)31(42-33(34)40)24(8)29(37)22(6)16-18(2)15-21(5)28(36)19(3)13-14-26(35)17-27-23(7)30(38)25(9)32(39)41-27/h10-15,19-31,35-38H,1,16-17H2,2-9H3,(H2,34,40)/b12-11+,14-13-,18-15-/t19?,20-,21+,22-,23+,24+,25-,26+,27+,28?,29+,30+,31+/m0/s1
InchiKey	AADVCYNFEREWOS-ZKGNTLCTSA-N
分子式 Formula	C33H55NO8
分子量 Molecular Weight	593.802
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Disermolide(CAS:127943-53-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Disermolide, also known as Discodermolide or (+)-Discodermolide is a polyketide natural product found to stabilize microtubules. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. Disermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Terwilliger DW, Trauner D. Selective Synthesis of Divergolide I. J Am Chem Soc. 2018 Feb 28;140(8):2748-275[1]doi: 10.1021/jacs.7b13092. Epub 2018 Feb 15. PubMed PMID: 29376358.

[2]Ding L, Franke J, Hertweck C. Divergolide congeners illuminate alternative reaction channels for ansamycin diversification. Org Biomol Chem. 2015 Feb 14;13(6):1618-23. doi: 10.1039/c4ob02244k. PubMed PMID: 25464499.

[3] Xu Z, Baunach M, Ding L, Peng H, Franke J, Hertweck C. Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte. Chembiochem. 2014 Jun 16;15(9):1274-9. doi: 10.1002/cbic.201402071. Epub 2014 May 27. PubMed PMID: 24867126.

[4] Li SR, Zhao GS, Sun MW, He HG, Wang HX, Li YY, Lu CH, Shen YM. Identification and characterization of the biosynthetic gene cluster of divergolides from Streptomyces sp. W112. Gene. 2014 Jul 1;544(1):93-9. doi: 10.1016/j.gene.2014.04.052. Epub 2014 Apr 24. PubMed PMID: 24768719.

[5] Nawrat CC, Kitson RR, Moody CJ. Toward the total synthesis of hygrocin B and divergolide C: construction of the naphthoquinone-azepinone core. Org Lett. 2014 Apr 4;16(7):1896-9. doi: 10.1021/ol5003847. Epub 2014 Mar 25. PubMed PMID: 24661134.

6: Rasapalli S, Jarugumilli G, Yarrapothu GR, Golen JA, Rheingold AL. Studies toward total synthesis of divergolides C and D. Org Lett. 2013 Apr 5;15(7):1736-9. doi: 10.1021/ol400528g. Epub 2013 Mar 25. PubMed PMID: 23527658.

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