3810-80-8|Diphenoxylate HCl|1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester hydrochloride|-范德生物科技公司

Diphenoxylate HCl

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names：
1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester hydrochloride
CAS号：
3810-80-8
MDL Number：
MF(分子式)： C30H33ClN2O2 MW(分子量)： 489.05
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Diphenoxylate HCl
英文别名	Diphenoxylate HCl; Diphenoxylate hydrochloride; R 1132; R-1132; R1132;
CAS号	3810-80-8
Inchi	InChI=1S/C30H32N2O2.ClH/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;/h3-17H,2,18-23H2,1H3;1H
InchiKey	SHTAFWKOISOCBI-UHFFFAOYSA-N
分子式 Formula	C30H33ClN2O2
分子量 Molecular Weight	489.05
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Diphenoxylate HCl(CAS:3810-80-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Diphenoxylate HCl was discontinued (DEA controlled substance, DEA Schedule V).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhu D, Chen S, Yao SK, Li YM, Chen SX. [Establishment of a canine slow transit constipation model and evalution of defecation, gastrointestinal transit and pathological sections]. Zhonghua Yi Xue Za Zhi. 2018 Jun 12;98(22):1786-179[1]doi: 10.3760/cma.j.issn.0376-2491.2018.22.012. Chinese. PubMed PMID: 29925160.

[2]Wang YB, Ling J, Zhang WZ, Li G, Qiu W, Zheng JH, Zhao XH. Effect of bisacodyl on rats with slow transit constipation. Braz J Med Biol Res. 2018;51(7):e7372. doi: 10.1590/1414-431x20187372. Epub 2018 May 28. PubMed PMID: 29846410; PubMed Central PMCID: PMC5995042.

[3] Zhai X, Lin D, Zhao Y, Yang X. Bacterial Cellulose Relieves Diphenoxylate-Induced Constipation in Rats. J Agric Food Chem. 2018 Apr 25;66(16):4106-4117. doi: 10.1021/acs.jafc.8b00385. Epub 2018 Apr 16. PubMed PMID: 29627986.

[4] Jiang F, Zhou JY, Wu J, Tian F, Zhu XX, Zhu CL, Yang BL, Chen YG. Yangyin Runchang Decoction Improves Intestinal Motility in Mice with Atropine/Diphenoxylate-Induced Slow-Transit Constipation. Evid Based Complement Alternat Med. 2017;2017:4249016. doi: 10.1155/2017/4249016. Epub 2017 Dec 18. PubMed PMID: 29403536; PubMed Central PMCID: PMC5748317.

[5] Tan P, Zhang HZ, Zhang DK, Wu SN, Niu M, Wang JB, Xiao XH. [Quality evaluation of rhubarb dispensing granules based on multi-component simultaneous quantitative analysis and bioassay]. Zhongguo Zhong Yao Za Zhi. 2017 Jul;42(14):2683-2690. doi: 10.19540/j.cnki.cjcmm.2017.0118. Chinese. PubMed PMID: 29098822.

6: Gao F, Sheng HM, Zhang TN, Wu SB, Cao J, Zhou MQ. [Effect of Manual Acupuncture Stimulation of Single Acupoint or Acupoints Combination on Intestinal Movement in Slow Transit Constipation Mice]. Zhen Ci Yan Jiu. 2017 Feb 25;42(1):62-6. Chinese. PubMed PMID: 29072000.7: Gawron AJ, Bielefeldt K. Risk of Pancreatitis Following Treatment of Irritable Bowel Syndrome With Eluxadoline. Clin Gastroenterol Hepatol. 2018 Mar;16(3):378-384.e2. doi: 10.1016/j.cgh.2017.08.006. Epub 2017 Aug 10. PubMed PMID: 28804032.8: Euwema MS, Swanson TJ. Toxicity, Deadly Single Dose Agents. 2017 Oct 6. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK441849/ PubMed PMID: 28722879.9: Luo D, Qu C, Zhang Z, Xie J, Xu L, Yang H, Li C, Lin G, Wang H, Su Z. Granularity and Laxative Effect of Ultrafine Powder of Dendrobium officinale. J Med Food. 2017 Feb;20(2):180-188. doi: 10.1089/jmf.2016.3827. PubMed PMID: 28146409.10: Ling J, Zhang W, Xu B, Qiu W, Wang Y. [Experimental study of Bisacodyl in the treatment of slow transit constipation model rats]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016 Dec 25;19(12):1365-1369. Chinese. PubMed PMID: 28000192.1

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