19895-66-0|Dianhydromannitol|(3R,4S)-hexa-1,5-diene-2,3,4,5-tetraol|-范德生物科技公司

Dianhydromannitol

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names：
(3R,4S)-hexa-1,5-diene-2,3,4,5-tetraol
CAS号：
19895-66-0
MDL Number：
MF(分子式)： C6H10O4 MW(分子量)： 146.14
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Dianhydromannitol
英文别名	Dianhydromannitol; DADM; NSC-133129; UNII-DPHVJPYRKV; 1256-Dianhydro-D-mannitol;
CAS号	19895-66-0
SMILES	C([C@@H]([C@@H](C(=C)O)O)O)(=C)O
Inchi	InChI=1S/C6H10O4/c1-3(7)5(9)6(10)4(2)8/h5-10H,1-2H2/t5-,6+
InchiKey	PICUSLXKOFIWAJ-OLQVQODUSA-N
分子式 Formula	C6H10O4
分子量 Molecular Weight	146.14
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dianhydromannitol(CAS:19895-66-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dianhydromannitol, Dihyro- and tetrahydrofuran building blocks from 1,43,6-dianhydromannitol. 1,2-Anhydro-6-bromo-6-deoxygalactitol (BrEpG) and its D-mannitol analogue (BrEpM) intermediary metabolites in the conversion of dibromodulcitol (DBD) and dibromomannitol (DBM) into dianhydrogalactitol (DAG) and dianhydromannitol (DAM) have been prepared. The three types of derivative of each hexitol have been compared in their toxicities towards mice, tumour inhibitory activities against the Walker carcinosarcoma and haematological effects in rats. The bromoepoxides showed intermediate potency in all tests. The galactitol derivatives were always more potent than their mannitol counterparts. The mannitol derivatives were selectively myelosuppressive, being twice as toxic towards granulocytes as towards lymphocytes. The lymphotoxic activity of DBM, in particular, relative to its other toxic effects was particularly mild. These differences have been ascribed principally to the more rapid reactivity of DAG compared with DAM towards target nucleophiles, modulated by the influence of the bromine substituent on the transport properties of the dibromo- and bromoepoxy-derivatives.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]GREGORY H, WIGGINS LF. Anhydrides of polyhydric alcohols; some alkenyl ethersof 1 : 4-3 : 6-dianhydromannitol and 1 ; 4-3 : 6-dianhydrosorbitol. J Chem Soc.1947 Oct:1405-7. PubMed PMID: 20272142.

[2]MONTGOMERY R, WIGGINS LF. Anhydrides of polyhydric alcohols;1:4-

[3]6-dianhydromannitol and 1:4-

3:6-dianhydro sorbitol from sucrose. J ChemSoc. 1947 Apr:433-6. PubMed PMID: 20249751.

[5] Horváth IP, Somfai-Relle S, Hegedüs L, Jarman M. Toxicity, antitumour andhaematological effects of 1,2-anhydro-6-bromogalactitol and d-mannitol: acomparison with the related dibromo- and dianhydro-derivatives. Eur J Cancer ClinOncol. 1982 Jun;18(6):573-7. PubMed PMID: 6811281.

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