3600-87-1|Desglymidodrine|alpha-(Aminomethyl)-2,5-dimethoxybenzenemethanol|-范德生物科技公司

Desglymidodrine

NMR下载 COA and HPLC MSDS下载
names：
alpha-(Aminomethyl)-2,5-dimethoxybenzenemethanol
CAS号：
3600-87-1
MDL Number：
MF(分子式)： C10H15NO3 MW(分子量)： 197.23
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Desglymidodrine
英文别名	Desglymidodrine
CAS号	3600-87-1
Inchi	InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
InchiKey	VFRCNXKYZVQYLX-UHFFFAOYSA-N
分子式 Formula	C10H15NO3
分子量 Molecular Weight	197.23
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Desglymidodrine(CAS:3600-87-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Desglymidodrine is a Metabolite of midodrine (ST-1085). It is used in plasma of ascitic patients.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ali AA, Al-Ghobashy MA, Farid SF, Kassem MA. Development and validation of LC-MS/MS assay for the determination of the prodrug Midodrine and its active metabolite Desglymidodrine in plasma of ascitic patients: Application to individualized therapy and comparative pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 1;991:34-40. doi: 10.1016/j.jchromb.2015.03.032. Epub 2015 Apr 7. PubMed PMID: 25910235.

[2]Barth T, Aleu J, Pupo MT, Bonato PS, Collado IG. HPLC analysis of midodrine and desglymidodrine in culture medium: evaluation of static and shaken conditions on the biotransformation by fungi. J Chromatogr Sci. 2013 May-Jun;51(5):460-7. doi: 10.1093/chromsci/bms163. Epub 2012 Oct 9. PubMed PMID: 23051063.

[3] Patel DP, Nair S, Suhagia BN, Patel BM. A novel, sensitive and selective method of UPLC/MS-MS for rapid simultaneous determination of midodrine and its active metabolite desglymidodrine in human plasma: Application to support bioequivalence study in healthy human volunteers. J Pharm Biomed Anal. 2016 Nov 30;131:355-363. doi: 10.1016/j.jpba.2016.09.005. Epub 2016 Sep 5. PubMed PMID: 27639073.

[4] Ali A, Farid S, Amin M, Kassem M, Al-Garem N, Al-Ghobashy M. Comparative Clinical Pharmacokinetics of Midodrine and Its Active Metabolite Desglymidodrine in Cirrhotic Patients with Tense Ascites Versus Healthy Volunteers. Clin Drug Investig. 2016 Feb;36(2):147-55. doi: 10.1007/s40261-015-0359-6. PubMed PMID: 26597181.

[5] Barth T, Pupo MT, Borges KB, Okano LT, Bonato PS. Stereoselective determination of midodrine and desglymidodrine in culture medium: application to a biotransformation study employing endophytic fungi. Electrophoresis. 2010 May;31(9):1521-8. doi: 10.1002/elps.200900685. PubMed PMID: 20376815.

6: Akimoto M, Iida I, Itoga H, Miyata A, Kawahara S, Kohno Y. The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2004 Jul-Sep;29(3):179-86. PubMed PMID: 15537169.7: Biaggioni I. New developments in the management of neurogenic orthostatic hypotension. Curr Cardiol Rep. 2014 Nov;16(11):542. doi: 10.1007/s11886-014-0542-z. Review. PubMed PMID: 25303896.8: Leduc BE, Fournier C, Jacquemin G, Lepage Y, Vinet B, Hétu PO, Chagnon M. Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study. J Spinal Cord Med. 2015 Jan;38(1):57-62. doi: 10.1179/2045772314Y.0000000225. Epub 2014 Jun 26. PubMed PMID: 24969635; PubMed Central PMCID: PMC4293534.9: Wright RA, Kaufmann HC, Perera R, Opfer-Gehrking TL, McElligott MA, Sheng KN, Low PA. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998 Jul;51(1):120-4. PubMed PMID: 9674789.10: Perazella MA. Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension. Expert Opin Drug Saf. 2003 Jan;2(1):37-47. Review. PubMed PMID: 12904123.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开