187852-63-7|Delimotecan|(S)-2-amino-N-(2-((2-((3-((4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4'6,7]indolizino[1,2-b]quinolin-9-yl)oxy)propyl)amino)-2-oxoethyl)amino)-2-oxoethyl)acetamide|-范德生物科技公司

Delimotecan

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names：
(S)-2-amino-N-(2-((2-((3-((4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4'6,7]indolizino[1,2-b]quinolin-9-yl)oxy)propyl)amino)-2-oxoethyl)amino)-2-oxoethyl)acetamide
CAS号：
187852-63-7
MDL Number：
MF(分子式)： C31H36N6O8 MW(分子量)： 620.663
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Delimotecan
英文别名	Delimotecan; MEN-4901; MEN4901; MEN 4901; T-0128; T 0128; T0128
CAS号	187852-63-7
Inchi	InChI=1S/C31H36N6O8/c1-3-18-19-10-17(44-9-5-8-33-26(39)13-35-27(40)14-34-25(38)12-32)6-7-23(19)36-28-20(18)15-37-24(28)11-22-21(29(37)41)16-45-30(42)31(22,43)4-2/h6-7,10-11,43H,3-5,8-9,12-16,32H2,1-2H3,(H,33,39)(H,34,38)(H,35,40)/t31-/m0/s1
InchiKey	MWOPHYKKEDTKAZ-HKBQPEDESA-N
分子式 Formula	C31H36N6O8
分子量 Molecular Weight	620.663
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Delimotecan(CAS:187852-63-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Delimotecan, also known as MEN-4901 and T-0128, is a DNA topoisomerase I inhibitor potentially for the treatment of solid tumors. Delimotecan had a long terminal half-life of 109 h, and relatively high exposures to T-2513 and SN-38 were obtained. The percentage decrease in WBC and absolute neutrophil count significantly correlated with the dose of delimotecan.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bigioni M, Parlani M, Bressan A, Bellarosa D, Rivoltini L, Animati F, Crea A, Bugianesi R, Maggi CA, Manzini S, Binaschi M. Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants. Int J Cancer. 2009 Nov 15;125(10):2456-64. doi: 10.1002/ijc.2466[1]PubMed PMID: 19536774.

[2]Veltkamp SA, Witteveen EO, Capriati A, Crea A, Animati F, Voogel-Fuchs M, van den Heuvel IJ, Beijnen JH, Voest EE, Schellens JH. Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors. Clin Cancer Res. 2008 Nov 15;14(22):7535-44. doi: 10.1158/1078-0432.CCR-08-0438. PubMed PMID: 19010872.

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