52423-28-6|Debromoaplysiatoxin|(1R,4R,13R,14S)-13-hydroxy-9-(1-hydroxyethyl)-3-(5-(3-hydroxyphenyl)-5-methoxypentan-2-yl)-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione|-范德生物科技公司

Debromoaplysiatoxin

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names：
(1R,4R,13R,14S)-13-hydroxy-9-(1-hydroxyethyl)-3-(5-(3-hydroxyphenyl)-5-methoxypentan-2-yl)-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione
CAS号：
52423-28-6
MDL Number：
MF(分子式)： C32H48O10 MW(分子量)： 592.726
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Debromoaplysiatoxin
英文别名	Debromoaplysiatoxin; Aplysiatoxin, 17-debromo-; G-2408; NSC 271679.
CAS号	52423-28-6
Inchi	InChI=1S/C32H48O10/c1-18(11-12-24(38-7)22-9-8-10-23(34)13-22)29-20(3)26-16-32(41-29)30(5,6)15-19(2)31(37,42-32)17-28(36)39-25(21(4)33)14-27(35)40-26/h8-10,13,18-21,24-26,29,33-34,37H,11-12,14-17H2,1-7H3/t18?,19-,20+,21?,24?,25?,26?,29?,31+,32+/m0/s1
InchiKey	REAZZDPREXHWNV-FNYQTHNFSA-N
分子式 Formula	C32H48O10
分子量 Molecular Weight	592.726
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Debromoaplysiatoxin(CAS:52423-28-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Debromoaplysiatoxin is a toxic agent produced by the blue-green alga Lyngbya majuscula. This alga lives in marine waters and causes seaweed dermatitis. Furthermore, it is a tumor promoter which has an anti-proliferative activity against various cancer cell lines in mice.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Richard K, Williams DE, de Silva ED, Brockman MA, Brumme ZL, Andersen RJ, Tietjen I. Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products. Viruses. 2018 Jun 27;10(7). pii: E348. doi: 10.3390/v10070348. PubMed PMID: 29954099; PubMed Central PMCID: PMC6071113.

[2]Han BN, Liang TT, Keen LJ, Fan TT, Zhang XD, Xu L, Zhao Q, Wang SP, Lin HW. Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K(+) Channel Inhibition Activity. Org Lett. 2018 Feb 2;20(3):578-581. doi: 10.1021/acs.orglett.7b03672. Epub 2018 Jan 18. PubMed PMID: 29345130.

[3] Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem Biophys Res Commun. 2018 Jan 1;495(1):438-445. doi: 10.1016/j.bbrc.2017.11.052. Epub 2017 Nov 9. PubMed PMID: 29129688.

[4] Puschner B, Bautista AC, Wong C. Debromoaplysiatoxin as the Causative Agent of Dermatitis in a Dog after Exposure to Freshwater in California. Front Vet Sci. 2017 Apr 6;

[5]50. doi: 10.3389/fvets.2017.00050. eCollection 2017. PubMed PMID: 28428958; PubMed Central PMCID: PMC5382154.

5: Kikumori M, Yanagita RC, Tokuda H, Suenaga K, Nagai H, Irie K. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead. Biosci Biotechnol Biochem. 2016;80(2):221-31. doi: 10.1080/09168451.2015.1091718. Epub 2015 Oct 9. PubMed PMID: 26452398.

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