86408-42-6|Deacetyl-N,O-didemethyldiltiazem|1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-5-(2-(methylamino)ethyl)-, (2S,3S)-|-范德生物科技公司

Deacetyl-N,O-didemethyldiltiazem

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names：
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-5-(2-(methylamino)ethyl)-, (2S,3S)-
CAS号：
86408-42-6
MDL Number：
MF(分子式)： C18H20N2O3S MW(分子量)： 344.429
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK14219-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Deacetyl-N,O-didemethyldiltiazem
英文别名	Deacetyl-N,O-didemethyldiltiazem; Deacetyl-N,O-didesmethyldiltiazem; N,O-Didemethyldeacetyldiltiazem; o-Desmethyldeacetylnordiltiazem.
CAS号	86408-42-6
Inchi	InChI=1S/C18H20N2O3S/c1-19-10-11-20-14-4-2-3-5-15(14)24-17(16(22)18(20)23)12-6-8-13(21)9-7-12/h2-9,16-17,19,21-22H,10-11H2,1H3/t16-,17+/m1/s1
InchiKey	ZTRZZXJIQHVVGS-SJORKVTESA-N
分子式 Formula	C18H20N2O3S
分子量 Molecular Weight	344.429
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Deacetyl-N,O-didemethyldiltiazem(CAS:86408-42-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Deacetyl-N,O-didemethyldiltiazem is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
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备注

[1]Zarev Y, Foubert K, Ionkova I, Apers S, Pieters L. Isolation and Structure Elucidation of Glucosylated Colchicinoids from the Seeds of Gloriosa superba by LC-DAD-SPE-NMR. J Nat Prod. 2017 Apr 28;80(4):1187-119[1]doi: 10.1021/acs.jnatprod.6b01024. Epub 2017 Feb 17. PubMed PMID: 28211687.

[2]Kumbhar BV, Borogaon A, Panda D, Kunwar A. Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. PLoS One. 2016 May 26;11(5):e0156048. doi: 10.1371/journal.pone.0156048. eCollection 2016. PubMed PMID: 27227832; PubMed Central PMCID: PMC4882049.

[3] Ho CT, Chang YJ, Yang LX, Wei PL, Liu TZ, Liu JJ. A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells. PLoS One. 2015 Sep 10;10(9):e0136340. doi: 10.1371/journal.pone.0136340. eCollection 2015. PubMed PMID: 26355599; PubMed Central PMCID: PMC4565632.

[4] Ab O, Whiteman KR, Bartle LM, Sun X, Singh R, Tavares D, LaBelle A, Payne G, Lutz RJ, Pinkas J, Goldmacher VS, Chittenden T, Lambert JM. IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14(7):1605-13. doi: 10.1158/1535-7163.MCT-14-1095. Epub 2015 Apr 22. PubMed PMID: 25904506.

[5] Hong EE, Erickson H, Lutz RJ, Whiteman KR, Jones G, Kovtun Y, Blanc V, Lambert JM. Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation. Mol Pharm. 2015 Jun 1;12(6):1703-16. doi: 10.1021/acs.molpharmaceut.5b00175. Epub 2015 Apr 27. PubMed PMID: 25856201.

6: Rai A, Gupta TK, Kini S, Kunwar A, Surolia A, Panda D. CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells. Biochem Pharmacol. 2013 Aug 1;86(3):378-91. doi: 10.1016/j.bcp.2013.05.024. Epub 2013 Jun 6. PubMed PMID: 23747346.7: Davis JA, Rock DA, Wienkers LC, Pearson JT. In vitro characterization of the drug-drug interaction potential of catabolites of antibody-maytansinoid conjugates. Drug Metab Dispos. 2012 Oct;40(10):1927-34. doi: 10.1124/dmd.112.046169. Epub 2012 Jun 29. PubMed PMID: 22752008.8: Yeung PK, Alcos A, Marcoux T, Tang J. Comparing pharmacokinetics and metabolism of diltiazem in normotensive Sprague Dawley and Wistar Kyoto rats vs. spontaneously hypertensive rats in vivo. Drug Metabol Drug Interact. 2011;26(3):119-25. doi: 10.1515/DMDI.2011.012. Epub 2011 Sep 20. PubMed PMID: 21929464.9: Al-Katib AM, Aboukameel A, Mohammad R, Bissery MC, Zuany-Amorim C. Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma. Clin Cancer Res. 2009 Jun 15;15(12):4038-45. doi: 10.1158/1078-0432.CCR-08-2808. Epub 2009 Jun 9. PubMed PMID: 19509168.10: Nevarez DM, Mengistu YA, Nawarathne IN, Walker KD. An N-aroyltransferase of the BAHD superfamily has broad aroyl CoA specificity in vitro with analogues of N-dearoylpaclitaxel. J Am Chem Soc. 2009 Apr 29;131(16):5994-6002. doi: 10.1021/ja900545m. PubMed PMID: 19382815.1

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