2355377-13-6|DDO-5936|N-(Mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine|-范德生物科技公司

DDO-5936

NMR下载 COA and HPLC MSDS下载
names：
N-(Mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine
CAS号：
2355377-13-6
MDL Number：
MF(分子式)： C25H29N5O4S MW(分子量)： 495.598
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	DDO-5936
英文别名	DDO-5936; DDO 5936; DDO5936;
CAS号	2355377-13-6
Inchi	InChI=1S/C25H29N5O4S/c1-17-14-18(2)24(19(3)15-17)35(33,34)30(16-23(31)32)21-8-6-20(7-9-21)27-22-10-11-26-25(28-22)29-12-4-5-13-29/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,31,32)(H,26,27,28)
InchiKey	IIPYRKNROAWEPK-UHFFFAOYSA-N
分子式 Formula	C25H29N5O4S
分子量 Molecular Weight	495.598
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DDO-5936(CAS:2355377-13-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DDO-5936 is a potent PPI inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI) as Orally Active Inhibitors for the Treatment of Colorectal Cancer. DDO-5936 disrupted the Hsp90-Cdc37 PPI both in vitro and in vivo via binding to a previously unknown site on Hsp90 involving Glu47, one of the binding determinants for the Hsp90-Cdc37 PPI, leading to selective down-regulation of Hsp90 kinase clients in HCT116 cells. In addition, inhibition of Hsp90-Cdc37 complex formation by DDO-5936 resulted in a remarkable cyclin-dependent kinase 4 decrease and consequent inhibition of cell proliferation through Cdc37-dependent cell cycle arrest.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wang L, Jiang J, Zhang L, Zhang Q, Zhou J, Li L, Xu X, You Q. Discovery andOptimization of Small Molecules Targeting the Protein-Protein Interaction of HeatShock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitorsfor the Treatment of Colorectal Cancer. J Med Chem. 2020 Jan 24. doi:10.1021/acs.jmedchem.9b01659. [Epub ahead of print] PubMed PMID: 31935086.

[2]Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X,Jiang Z, Zhang J, You Q. Small-molecule inhibitor targeting the Hsp90-Cdc37protein-protein interaction in colorectal cancer. Sci Adv. 2019 Sep18;5(9):eaax2277. doi: 10.1126/sciadv.aax2277. eCollection 2019 Sep. PubMed PMID:31555737; PubMed Central PMCID: PMC6750927.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开