131420-84-3|DA-E 5090|(Z)-3-(5-Ethyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acid|-范德生物科技公司

DA-E 5090

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names：
(Z)-3-(5-Ethyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acid
CAS号：
131420-84-3
MDL Number：
MF(分子式)： C17H18O4 MW(分子量)： 286.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	DA-E 5090
英文别名	DA-E 5090; DA-E5090; DA E 5090; DA-E-5090; DA-E-5090;
CAS号	131420-84-3
Inchi	InChI=1S/C17H18O4/c1-4-11-6-5-7-13-12(8-10(2)17(19)20)9-14(21-3)16(18)15(11)13/h5-9,18H,4H2,1-3H3,(H,19,20)/b10-8-
InchiKey	WGNQQQSMLCOUAX-NTMALXAHSA-N
分子式 Formula	C17H18O4
分子量 Molecular Weight	286.33
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DA-E 5090(CAS:131420-84-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DA-E 5090 is deacetylated form of E5090, is pharmacologically active metabolite of E 5090, is interleukin-1 antagonist. DA-E 5090 is a novel inhibitor of IL-1 generation, in vitro inhibitory effects on the generation of IL-1 by human monocytes. E5090 is an orally active inhibitor of IL-1 generation, being converted in vivo into the pharmacologically active deacetylated form (DA-E5090). In vitro effects of DA-E5090 on the generation of IL-1 by human monocytes stimulated with LPS were examined. DA-E5090 inhibited both IL-1 alpha and IL-1 beta generation by human monocytes stimulated with 1 microgram/ml of LPS in a dose dependent-manner (1-10 microM), as determined by LAF assay and ELISA. Northern blotting analysis indicated that DA-E5090 inhibits transcription of IL-1 alpha and IL-1 beta m-RNAs.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tanaka M, Chiba K, Okita M, Kaneko T, Tagami K, Hibi S, Okamoto Y, Shirota H, Goto M, Sakurai H, et al. 3-(5-Alkyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acids as orally active inhibitors of IL-1 generation. J Med Chem. 1991 Aug;34(8):2647-9. PubMed PMID: 1875355.

[2]Goto M, Chiba K, Hashida R, Shirota H. A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes. Agents Actions Suppl. 1991;3

2:225-9. PubMed PMID: 2069091.

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