174661-97-3|DA 5018|2-(4-(2-aminoethoxy)-3-methoxyphenyl)-N-(3-(3,4-dimethylphenyl)propyl)acetamide hydrochloride|-范德生物科技公司

DA 5018

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names：
2-(4-(2-aminoethoxy)-3-methoxyphenyl)-N-(3-(3,4-dimethylphenyl)propyl)acetamide hydrochloride
CAS号：
174661-97-3
MDL Number：
MF(分子式)： C22H31ClN2O3 MW(分子量)： 406.95
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK14026-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	DA 5018
英文别名	DA 5018; DA-5018; DA5018;UNII-51V6N8BA2P;
CAS号	174661-97-3
Inchi	InChI=1S/C22H30N2O3.ClH/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3;/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25);1H
InchiKey	OUEKLNJUMVZULZ-UHFFFAOYSA-N
分子式 Formula	C22H31ClN2O3
分子量 Molecular Weight	406.95
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DA 5018(CAS:174661-97-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DA 5018 is a capsaicin derivative, it has the antipruritic effect. DA 5018 is also a new non-narcotic analgesic.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kim DH, Ahn BO, Kim SH, Kim WB. Antipruritic effect of DA-5018, a capsaicin derivative, in mice. Arch Pharm Res. 1999 Dec;22(6):549-53. PubMed PMID: 10615858.

[2]Kang YS, Kim JM. Permeability of a capsaicin derivative, [14C]DA-5018 to blood-brain barrier corrected with HPLC method. Arch Pharm Res. 1999 Apr;22(2):165-72. PubMed PMID: 10230507.

[3] Lee JJ, Shim HJ, Kim SH, Lee SD, Kim WB, Yang J, Lee MG. Pharmacokinetics of a non-narcotic analgesic, DA-5018, in rats. Biopharm Drug Dispos. 1998 Mar;19(2):101-8. PubMed PMID: 9533110.

[4] Shim HJ, Lee JJ, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Stability, blood partition, and protein binding of DA-5018, a new nonnarcotic analgesic. Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):97-108. PubMed PMID: 8824935.

[5] Cha BJ, Lee ED, Kim WB, Chung SJ, Lee MH, Shim CK. Enhanced skin permeation of a new capsaicin derivative (DA-5018) from a binary vehicle system composed of isopropyl myristate and ethoxydiglycol. Arch Pharm Res. 2001 Jun;24(3):224-8. PubMed PMID: 11440082.

6: Shim HJ, Lee JJ, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Determination of a new non-narcotic analgesic, DA-5018, in plasma, urine and bile by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Feb 21;689(2):422-6. PubMed PMID: 9080332.7: Park YH, You ES, Kim WB, Lee SS. DA-5018, a novel vanilloid type analgesic. Arch Pharm Res. 1997 Feb;20(1):93-5. PubMed PMID: 18975221.8: Jung J, Hwang SW, Kwak J, Lee SY, Kang CJ, Kim WB, Kim D, Oh U. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci. 1999 Jan 15;19(2):529-38. PubMed PMID: 9880573.9: Shin JS, Wang MH, Hwang SW, Cho H, Cho SY, Kwon MJ, Lee SY, Oh U. Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists. Neurosci Lett. 2001 Feb 16;299(1-2):135-9. PubMed PMID: 11166956.10: Pearce LV, Toth A, Ryu H, Kang DW, Choi HK, Jin MK, Lee J, Blumberg PM. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2008 Apr;377(2):149-57. doi: 10.1007/s00210-007-0258-3. Epub 2008 Feb 8. PubMed PMID: 18259730; PubMed Central PMCID: PMC2931423.1

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