169285-98-7|DA 1131|(4R,5S)-6-(1-hydroxyethyl)-4-methyl-3-(((3S,5S)-5-((E)-3-(methylsulfonamido)prop-1-en-1-yl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid|-范德生物科技公司

DA 1131

NMR下载 COA and HPLC MSDS下载
names：
(4R,5S)-6-(1-hydroxyethyl)-4-methyl-3-(((3S,5S)-5-((E)-3-(methylsulfonamido)prop-1-en-1-yl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS号：
169285-98-7
MDL Number：
MF(分子式)： C18H27N3O6S2 MW(分子量)： 445.55
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	DA 1131
英文别名	DA 1131; DA-1131; DA1131;
CAS号	169285-98-7
SMILES	C[C@@H]1[C@@H]2C(C(=O)N2C(=C1S[C@H]3C[C@H](NC3)/C=C/CNS(=O)(=O)C)C(=O)O)C(C)O
Inchi	InChI=1S/C18H27N3O6S2/c1-9-14-13(10(2)22)17(23)21(14)15(18(24)25)16(9)28-12-7-11(19-8-12)5-4-6-20-29(3,26)27/h4-5,9-14,19-20,22H,6-8H2,1-3H3,(H,24,25)/b5-4+/t9-,10?,11-,12+,13?,14-/m1/s1
InchiKey	UXCCOLVNQUBDAJ-FGQVXFQSSA-N
分子式 Formula	C18H27N3O6S2
分子量 Molecular Weight	445.55
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DA 1131(CAS:169285-98-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DA 1131 is a new carbapenem antibiotic, undergoes renal metabolism by renal dehydropeptidase I (DHP-I), located on the brush border of the proximal tubular cell. Species differences with the effects of cilastatin, a renal DHP-I inhibitor, after a 1-min intravenous infusion of DA-1131, with or without cilastatin, to rats, rabbits, and dogs.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kim SH, Kim WB, Lee MG. Effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in rats and rabbits. Antimicrob Agents Chemother. 1999 Jan;43(1):96-9. PubMed PMID: 9869572; PubMed Central PMCID: PMC89027.

[2]Kim SH, Shim HJ, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure. Antimicrob Agents Chemother. 1998 May;42(5):1217-21. PubMed PMID: 9593153; PubMed Central PMCID: PMC105781.

[3] Kim SH, Kwon JW, Lee MG. Pharmacokinetics and tissue distribution of a new carbapenem DA-1131, after intravenous administration to mice, rats, rabbits and dogs. Biopharm Drug Dispos. 1998 May;19(4):219-29. PubMed PMID: 9604121.

[4] Kim SH, Kwon JW, Kim WB, Lee MG. Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Antimicrob Agents Chemother. 1999 Oct;43(10):2524-7. PubMed PMID: 10508037; PubMed Central PMCID: PMC89513.

[5] Kim SH, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with alloxan-induced diabetes mellitus. Biopharm Drug Dispos. 1998 Jul;19(5):303-8. PubMed PMID: 9673782.

6: Park SW, We JS, Kim GW, Choi SH, Park HS. Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). Antimicrob Agents Chemother. 2002 Feb;46(2):575-7. PubMed PMID: 11796382; PubMed Central PMCID: PMC127065.7: Kim SH, Kim WB, Kwon JW, Lee MG. Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits. Biopharm Drug Dispos. 1999 Apr;20(3):125-9. PubMed PMID: 10211864.8: Kim SH, Kim WB, Lee MG. No effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in dogs. Res Commun Mol Pathol Pharmacol. 1998 Jul;101(1):85-92. PubMed PMID: 9755846.9: Kim SH, Kwon JW, Kim WB, Lee I, Lee MG. Effects of water deprivation for 72 hours on the pharmacokinetics of a new carbapenem, DA-1131, in rats. Life Sci. 2002 Sep 27;71(19):2291-8. PubMed PMID: 12215376.10: Kim SH, Kim WB, Lee MG. Interspecies pharmacokinetic scaling of a new carbapenem, DA-1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics. Biopharm Drug Dispos. 1998 May;19(4):231-5. PubMed PMID: 9604122.1

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