204980-81-4|CX-659S|2H-1-Benzopyran-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)-|-范德生物科技公司

CX-659S

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names：
2H-1-Benzopyran-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)-
CAS号：
204980-81-4
MDL Number：
MF(分子式)： C25H28N4O5 MW(分子量)： 464.51
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CX-659S
英文别名	CX-659S; CX 659S; CX659S; UNII-YG2F04AVMQ.
CAS号	204980-81-4
Inchi	InChI=1S/C25H28N4O5/c1-13-14(2)20-17(15(3)19(13)30)11-12-25(4,34-20)23(32)27-18-21(26)29(16-9-7-6-8-10-16)24(33)28(5)22(18)31/h6-10,30H,11-12,26H2,1-5H3,(H,27,32)/t25-/m0/s1
InchiKey	NOYZWUQUALADDO-VWLOTQADSA-N
分子式 Formula	C25H28N4O5
分子量 Molecular Weight	464.51
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CX-659S(CAS:204980-81-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CX-659S is a novel diaminouracil derivative that has an inhibitory effect on hapten-induced contact hypersensitivity reaction in mice. CX-659S indirectly inhibits the function of Langerhans cells by blocking the MEK1/2-Erk1/2 pathway in keratinocytes.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tobe M, Tsuboi K, Hasegawa F, Fujiwara N, Inoue Y, Isobe M, Isobe Y. Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1292-5. doi: 10.1016/j.bmcl.2016.01.019. Epub 2016 Jan 8. PubMed PMID: 26786694.

[2]Kido M, Takeuchi S, Esaki H, Hayashida S, Furue M. Scratching behavior does not necessarily correlate with epidermal nerve fiber sprouting or inflammatory cell infiltration. J Dermatol Sci. 2010 May;58(2):130-5. doi: 10.1016/j.jdermsci.2010.03.007. Epub 2010 Mar 19. PubMed PMID: 20399618.

[3] Ohmori K, Adachi K, Manabe H, Harada D, Ohshima E. [Recent development of new drugs for the treatment of allergic diseases]. Nihon Yakurigaku Zasshi. 2004 May;123(5):335-48. Review. Japanese. PubMed PMID: 15118258.

[4] Isobe Y, Tobe M, Inoue Y, Isobe M, Tsuchiya M, Hayashi H. Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents. Bioorg Med Chem. 2003 Nov 17;11(23):4933-40. PubMed PMID: 14604654.

[5] Inoue Y, Isobe M, Shiohara T, Hayashi H. Inhibitory activity of CX-659S, a novel diaminouracil derivative, against the rebound phenomenon following withdrawal of corticosteroid therapy for chronic contact hypersensitivity responses. Int Arch Allergy Immunol. 2003 Jun;131(2):143-52. PubMed PMID: 12811023.

6: Uchi H, Koga T, Urabe K, Moroi Y, Furue M. CX-659S, a diaminouracil derivative, indirectly inhibits the function of Langerhans cells by blocking the MEK1/2-Erk1/2 pathway in keratinocytes. J Invest Dermatol. 2003 Jun;120(6):983-9. PubMed PMID: 12787125.7: Inoue Y, Isobe M, Hayashi H. The combined effect of topical CX-659S, a novel diaminouracil derivative, with topical corticosteroid on the three types of allergic responses in mice or guinea pigs. J Pharmacol Sci. 2003 Jan;91(1):71-8. PubMed PMID: 12686733.8: Isobe Y, Tobe M, Takahashi O, Goto Y, Inoue Y, Obara F, Tsuchiya M, Hayashi H. Synthesis and activity of a metabolite of (S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phe nyl-2,4-(1H,3H)-pyrimidinedione (CX-659S). Chem Pharm Bull (Tokyo). 2002 Oct;50(10):1418-20. PubMed PMID: 12372880.9: Inoue Y, Isobe M, Shiohara T, Goto Y, Hayashi H. Protective and curative effects of topically applied CX-659S, a novel diaminouracil derivative, on chronic picryl chloride-induced contact hypersensitivity responses. Br J Dermatol. 2002 Oct;147(4):675-82. PubMed PMID: 12366412.10: Goto Y, Watanabe N, Kogawa N, Tsuchiya M, Takahashi O, Uchi H, Furue M, Hayashi H. CX-659S: a novel diaminouracil derivative that has antioxidative and acute anti-inflammatory activities. Eur J Pharmacol. 2002 Mar 8;438(3):189-96. PubMed PMID: 11909611.1

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