166981-13-1|CT-2584|1-(11-(dodecylamino)-10-hydroxyundecyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione|-范德生物科技公司

CT-2584

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names：
1-(11-(dodecylamino)-10-hydroxyundecyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
CAS号：
166981-13-1
MDL Number：
MF(分子式)： C30H55N5O3 MW(分子量)： 533.802
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CT-2584
英文别名	CT-2584; CT2584; CT 2584.
CAS号	166981-13-1
Inchi	InChI=1S/C30H55N5O3/c1-4-5-6-7-8-9-10-13-16-19-22-31-24-26(36)21-18-15-12-11-14-17-20-23-35-29(37)27-28(32-25-33(27)2)34(3)30(35)38/h25-26,31,36H,4-24H2,1-3H3
InchiKey	MZNMZWZGUGFQJP-UHFFFAOYSA-N
分子式 Formula	C30H55N5O3
分子量 Molecular Weight	533.802
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CT-2584(CAS:166981-13-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor potentially for the treatment of cancer. CT-2584 inhibits phospholipid signaling. By inhibiting CTPcholine-phosphate cytidylyltransferase (CT), CT-2584 caused de novo phospholipid biosynthesis via PA to be shunted away from phosphatidylcholine (PC) and into phosphatidylinositol (PI), the latter of which was doubled in a variety of CT-2584-treated tumor cell lines. CT-2584 effects a novel mechanism of cytotoxicity to cancer cells, involving a specific modulation of phospholipid metabolism.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bonfil RD. CT-2584 (Cell Therapeutics). Curr Opin Investig Drugs. 2001 Mar;2(3):424-7. PubMed PMID: 11575717.

[2]Cheeseman SL, Brannan M, McGown A, Khan P, Gardner C, Gumbrell L, Dickens D, Ranson M. Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumours. Br J Cancer. 2000 Dec;83(12):1599-606. PubMed PMID: 11104552; PubMed Central PMCID: PMC2363467.

[3] Finney RE, Nudelman E, White T, Bursten S, Klein P, Leer LL, Wang N, Waggoner D, Singer JW, Lewis RA. Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. Cancer Res. 2000 Sep 15;60(18):5204-13. PubMed PMID: 11016649.

[4] Khan P, Abbas S, Cheeseman S, Ranson M, McGown AT. Development and validation of a sensitive solid-phase extraction and high-performance liquid chromatography assay for the novel antitumour agent CT2584 in human plasma. J Chromatogr B Biomed Sci Appl. 1999 Jan 22;721(2):279-84. PubMed PMID: 10052700.

[5] Phase I clinical data on novel anticancer, antiangiogenesis drug. Oncology (Williston Park). 1998 Sep;12(9):1395. PubMed PMID: 9778687.

6: Marucci L, Varticovski L, Arias IM. Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice. Hepatology. 1997 Nov;26(5):1195-202. PubMed PMID: 9362362.7: Shau H, Kim AT, Hedrick CC, Lusis AJ, Tompkins C, Finney R, Leung DW, Paglia DE. Endogenous natural killer enhancing factor-B increases cellular resistance to oxidative stresses. Free Radic Biol Med. 1997;22(3):497-507. PubMed PMID: 8981042.8: MOUNT RA, FLOYD TM. A dysentery outbreak aboard a cruiser in Apra Harbor, Guam, Marianas Islands. U S Nav Med Bull. 1948 Mar-Apr;48(2):240-9. PubMed PMID: 18906975.

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