305821-96-9|CP-472555|2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propyn-1-yl)-N-(3-pyridinylmethyl)-, (4bS,7R,8aR)-|-范德生物科技公司

CP-472555

NMR下载 COA and HPLC MSDS下载
names：
2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propyn-1-yl)-N-(3-pyridinylmethyl)-, (4bS,7R,8aR)-
CAS号：
305821-96-9
MDL Number：
MF(分子式)： C31H32N2O2 MW(分子量)： 464.6
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CP-472555
英文别名	CP-472555; CP 472555; CP472555; UNII-6T0KV7024R.
CAS号	305821-96-9
SMILES	CC#C[C@]1(CC[C@]2(c3ccc(cc3CC[C@@H]2C1)C(=O)NCc4cccnc4)Cc5ccccc5)O
Inchi	InChI=1S/C31H32N2O2/c1-2-14-30(35)15-16-31(19-23-7-4-3-5-8-23)27(20-30)12-10-25-18-26(11-13-28(25)31)29(34)33-22-24-9-6-17-32-21-24/h3-9,11,13,17-18,21,27,35H,10,12,15-16,19-20,22H2,1H3,(H,33,34)/t27-,30-,31+/m1/s1
InchiKey	SEOPOTXFVGEDGX-UPHHSBJESA-N
分子式 Formula	C31H32N2O2
分子量 Molecular Weight	464.6
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CP-472555(CAS:305821-96-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CP-472555 is a selective, nonsteroidal glucocorticoid receptor antagonist, with anti-GR and anti-obesity activity in animal models.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Briski KP, Kale AY, Vavaiya KV. Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors. Exp Brain Res. 2009 Jun;195(4):499-507. doi: 10.1007/s00221-009-1787-4. Epub 2009 May 6. PubMed PMID: 19418044.

[2]Kale AY, Paranjape SA, Briski KP. Type II glucocorticoid receptor involvement in habituated activation of lateral hypothalamic area orexin-A-immunopositive neurons during recurring insulin-induced hypoglycemia. Neurosci Res. 2006 Nov;56(3):309-13. Epub 2006 Sep 25. PubMed PMID: 16997409.

[3] Kale AY, Vavaiya KV, Briski KP. Effects of acute and chronic insulin-induced hypoglycemia on type II glucocorticoid receptor (GR) gene expression in characterized CNS metabolic loci. Brain Res Bull. 2006 Jul 31;70(3):240-4. Epub 2006 Jun 6. PubMed PMID: 16861109.

[4] Kale AY, Paranjape SA, Briski KP. Site-specific habituation of insulin-induced hypoglycemic induction of fos immunoreactivity in glucocorticoid receptor: immunopositive neurons in the male rat brain. Exp Brain Res. 2007 Jan;176(2):260-6. PubMed PMID: 16850320.

[5] Kale AY, Paranjape SA, Briski KP. I.c.v. administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration. Neuroscience. 2006 Jun 30;140(2):555-65. Epub 2006 Apr 19. PubMed PMID: 16626867.

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