154212-56-3|Cosalane|Benzoic acid, 3,3'-(4-(3beta,5alpha)-cholestan-3-yl-1-butenylidene)bis(5-chloro-6-hydroxy-|-范德生物科技公司

Cosalane

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names：
Benzoic acid, 3,3'-(4-(3beta,5alpha)-cholestan-3-yl-1-butenylidene)bis(5-chloro-6-hydroxy-
CAS号：
154212-56-3
MDL Number：
MF(分子式)： C45H60Cl2O6 MW(分子量)： 767.869
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Cosalane
英文别名	Cosalane; NSC 658586; NSC-658586
CAS号	154212-56-3
Inchi	InChI=1S/C45H60Cl2O6/c1-25(2)8-6-9-26(3)35-14-15-36-32-13-12-30-20-27(16-18-44(30,4)37(32)17-19-45(35,36)5)10-7-11-31(28-21-33(42(50)51)40(48)38(46)23-28)29-22-34(43(52)53)41(49)39(47)24-29/h11,21-27,30,32,35-37,48-49H,6-10,12-20H2,1-5H3,(H,50,51)(H,52,53)/t26-,27+,30+,32+,35-,36+,37+,44+,45-/m1/s1
InchiKey	VOJOOGPALCATLT-ZFQBPCNVSA-N
分子式 Formula	C45H60Cl2O6
分子量 Molecular Weight	767.869
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cosalane(CAS:154212-56-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cosalane is active against a variety of HIV-1 strains and HIV-2. The compound inhibits the binding of gp120 to CD4 cells and of the postbinding events that lead to fusion of the virus with the cell membrane.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Casimiro-Garcia A, De Clercq E, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW Jr, Fanwick PE, Cushman M. Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments. Bioorg Med Chem. 2001 Nov;9(11):2827-4[1]PubMed PMID: 11597463.

[2]Zhan P, Li Z, Liu X. Cosalane and its analogues: a unique class of anti-HIV agents. Mini Rev Med Chem. 2010 Sep;10(10):966-76. Review. PubMed PMID: 20540707.

[3] Golebiewski WM, Keyes RF, Cushman M. Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. Bioorg Med Chem. 1996 Oct;4(10):1637-48. PubMed PMID: 8931933.

[4] Kuchimanchi KR, Gandhi MD, Sheta RR, Johnston TP, Santhosh KC, Cushman M, Mitra AK. Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents. Int J Pharm. 2002 Jan 14;231(2):197-211. PubMed PMID: 11755272.

[5] Santhosh KC, De Clercq E, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Cushman M. Anti-HIV activity of a series of cosalane amino acid conjugates. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2505-8. PubMed PMID: 11086716.

6: Udata C, Patel J, Pal D, Hejchman E, Cushman M, Mitra AK. Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. Int J Pharm. 2003 Jan 2;250(1):157-68. PubMed PMID: 12480282.7: Cushman M, Golebiewski WM, McMahon JB, Buckheit RW Jr, Clanton DJ, Weislow O, Haugwitz RD, Bader JP, Graham L, Rice WG. Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. J Med Chem. 1994 Sep 16;37(19):3040-50. PubMed PMID: 7932526.8: Venkatesh S, Li J, Xu Y, Vishnuvajjala R, Anderson BD. Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586), an extremely hydrophobic diprotic acid. Pharm Res. 1996 Oct;13(10):1453-9. PubMed PMID: 8899834.9: Choo V. Anti-HIV activity of cosalane. Lancet. 1993 Sep 18;342(8873):733. PubMed PMID: 8103830.10: Casimiro-Garcia A, De Clercq E, Pannecouque C, Witvrouw M, Stup TL, Turpin JA, Buckheit RW Jr, Cushman M. Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. Bioorg Med Chem. 2000 Jan;8(1):191-200. PubMed PMID: 10968278.1

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