1018679-79-2|CORT-108297|(R)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline|-范德生物科技公司

CORT-108297

NMR下载 COA and HPLC MSDS下载
names：
(R)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline
CAS号：
1018679-79-2
MDL Number：
MF(分子式)： C26H25F4N3O3S MW(分子量)： 535.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CORT-108297
英文别名	CORT-108297; CORT 108297; CORT108297; C-108927; C 108927; C108927
CAS号	1018679-79-2
Inchi	InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1
InchiKey	SLKURXRZHJOZOD-RUZDIDTESA-N
分子式 Formula	C26H25F4N3O3S
分子量 Molecular Weight	535.56
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CORT-108297(CAS:1018679-79-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CORT-108297 is discontinued.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Solomon MB, Wulsin AC, Rice T, Wick D, Myers B, McKlveen J, Flak JN, Ulrich-Lai Y, Herman JP. The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test. Horm Behav. 2014 Apr;65(4):363-7[1]doi: 10.1016/j.yhbeh.2014.02.002. PubMed PMID: 24530653; PubMed Central PMCID: PMC4074011.

[2]Sindelar DK, Carson MW, Morin M, Shaw J, Barr RJ, Need A, Alexander-Chacko J, Coghlan M, Gehlert DR. LLY-2707, a novel nonsteroidal glucocorticoid antagonist that reduces atypical antipsychotic-associated weight gain in rats. J Pharmacol Exp Ther. 2014 Jan;348(1):192-201. doi: 10.1124/jpet.113.205864. PubMed PMID: 24163440.

[3] Belanoff JK, Blasey CM, Clark RD, Roe RL. Selective glucocorticoid receptor (type II) antagonist prevents and reverses olanzapine-induced weight gain. Diabetes Obes Metab. 2010 Jun;12(6):545-7. doi: 10.1111/j.1463-1326.2009.01185.x. PubMed PMID: 20518810.

[4] Asagami T, Belanoff JK, Azuma J, Blasey CM, Clark RD, Tsao PS. Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. J Nutr Metab. 2011;2011:235389. doi: 10.1155/2011/235389. PubMed PMID: 21811679; PubMed Central PMCID: PMC3146995.

[5] Andrade C, Shaikh SA, Narayan L, Blasey C, Belanoff J. Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia. J Neural Transm (Vienna). 2012 Mar;119(3):337-44. doi: 10.1007/s00702-011-0712-8. PubMed PMID: 21922193.

6: Butts KA, Phillips AG. Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. Int J Neuropsychopharmacol. 2013 Sep;16(8):1799-807. doi: 10.1017/S1461145713000187. PubMed PMID: 23590841.7: Meyer M, Gonzalez Deniselle MC, Hunt H, de Kloet ER, De Nicola AF. The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice. J Steroid Biochem Mol Biol. 2014 Sep;14

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