1018679-79-2|CORT-108297|(R)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline|-范德生物科技公司

CORT-108297

NMR下载 COA and HPLC MSDS下载
names：
(R)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline
CAS号：
1018679-79-2
MDL Number：
MF(分子式)： C26H25F4N3O3S MW(分子量)： 535.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CORT-108297
英文别名	CORT-108297; CORT 108297; CORT108297; C-108927; C 108927; C108927
CAS号	1018679-79-2
SMILES	O=S(N1C[C@@]2(COCC)CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C2CC1)(C5=CC=C(C(F)(F)F)C=C5)=O
Inchi	InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1
InchiKey	SLKURXRZHJOZOD-RUZDIDTESA-N
分子式 Formula	C26H25F4N3O3S
分子量 Molecular Weight	535.56
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CORT-108297(CAS:1018679-79-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CORT-108297 is discontinued.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Solomon MB, Wulsin AC, Rice T, Wick D, Myers B, McKlveen J, Flak JN, Ulrich-Lai Y, Herman JP. The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test. Horm Behav. 2014 Apr;65(4):363-7[1]doi: 10.1016/j.yhbeh.2014.02.002. PubMed PMID: 24530653; PubMed Central PMCID: PMC4074011.

[2]Sindelar DK, Carson MW, Morin M, Shaw J, Barr RJ, Need A, Alexander-Chacko J, Coghlan M, Gehlert DR. LLY-2707, a novel nonsteroidal glucocorticoid antagonist that reduces atypical antipsychotic-associated weight gain in rats. J Pharmacol Exp Ther. 2014 Jan;348(1):192-201. doi: 10.1124/jpet.113.205864. PubMed PMID: 24163440.

[3] Belanoff JK, Blasey CM, Clark RD, Roe RL. Selective glucocorticoid receptor (type II) antagonist prevents and reverses olanzapine-induced weight gain. Diabetes Obes Metab. 2010 Jun;12(6):545-7. doi: 10.1111/j.1463-1326.2009.01185.x. PubMed PMID: 20518810.

[4] Asagami T, Belanoff JK, Azuma J, Blasey CM, Clark RD, Tsao PS. Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. J Nutr Metab. 2011;2011:235389. doi: 10.1155/2011/235389. PubMed PMID: 21811679; PubMed Central PMCID: PMC3146995.

[5] Andrade C, Shaikh SA, Narayan L, Blasey C, Belanoff J. Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia. J Neural Transm (Vienna). 2012 Mar;119(3):337-44. doi: 10.1007/s00702-011-0712-8. PubMed PMID: 21922193.

6: Butts KA, Phillips AG. Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. Int J Neuropsychopharmacol. 2013 Sep;16(8):1799-807. doi: 10.1017/S1461145713000187. PubMed PMID: 23590841.7: Meyer M, Gonzalez Deniselle MC, Hunt H, de Kloet ER, De Nicola AF. The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice. J Steroid Biochem Mol Biol. 2014 Sep;14

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