105798-74-1|Clitocine|(2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol|-范德生物科技公司

Clitocine

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names：
(2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
CAS号：
105798-74-1
MDL Number：
MF(分子式)： C9H13N5O6 MW(分子量)： 287.23
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Clitocine
英文别名	Clitocine;
CAS号	105798-74-1
Inchi	InChI=1S/C9H13N5O6/c10-7-4(14(18)19)8(12-2-11-7)13-9-6(17)5(16)3(1-15)20-9/h2-3,5-6,9,15-17H,1H2,(H3,10,11,12,13)/t3-,5-,6-,9-/m1/s1
InchiKey	OHEMBWZZEKCBAS-UUOKFMHZSA-N
分子式 Formula	C9H13N5O6
分子量 Molecular Weight	287.23
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Clitocine(CAS:105798-74-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Clitocine is a potent and efficacious readthrough agent. It acts by inducing the production of p53 protein in cells harboring p53 nonsense-mutated alleles.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Friesen WJ, Trotta CR, Tomizawa Y, Zhuo J, Johnson B, Sierra J, Roy B, Weetall M, Hedrick J, Sheedy J, Takasugi J, Moon YC, Babu S, Baiazitov R, Leszyk JD, Davis TW, Colacino JM, Peltz SW, Welch EM. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017 Apr;23(4):567-577. doi: 10.1261/rna.060236.116. Epub 2017 Jan 17. PubMed PMID: 28096517; PubMed Central PMCID: PMC5340919.

[2]Sun JG, Ruan F, Zeng XL, Xiang J, Li X, Wu P, Fung KP, Liu FY. Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis. 2016 Oct;21(10):1144-57. doi: 10.1007/s10495-016-1273-y. PubMed PMID: 27421828.

[3] Sun JG, Xiang J, Zeng XL, Li X, Wu P, Fung KP, Liu FY. Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. Cancer Lett. 2014 Dec 28;355(2):253-63. doi: 10.1016/j.canlet.2014.09.024. Epub 2014 Oct 7. PubMed PMID: 25304383.

[4] Sun JG, Li H, Li X, Zeng X, Wu P, Fung KP, Liu FY. Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo. Apoptosis. 2014 May;19(5):871-82. doi: 10.1007/s10495-014-0969-0. PubMed PMID: 24563182.

[5] Sun J, Yeung CA, Co NN, Tsang TY, Yau E, Luo K, Wu P, Wa JC, Fung KP, Kwok TT, Liu F. Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line. PLoS One. 2012;7(8):e40720. doi: 10.1371/journal.pone.0040720. Epub 2012 Aug 22. PubMed PMID: 22927901; PubMed Central PMCID: PMC3425549.

6: Ren G, Zhao YP, Yang L, Fu CX. Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. Cancer Lett. 2008 Apr 18;262(2):190-200. doi: 10.1016/j.canlet.2007.12.013. Epub 2008 Jan 25. PubMed PMID: 18222036.7: Fortin H, Tomasi S, Delcros JG, Bansard JY, Boustie J. In vivo antitumor activity of clitocine, an exocyclic amino nucleoside isolated from Lepista inversa. ChemMedChem. 2006 Feb;1(2):189-96. PubMed PMID: 16892351.8: Varaprasad CV, Habib Q, An H, Hong Z. Solid-phase synthesis of 5'-deoxy-5'-amino-clitocine analogues. Nucleosides Nucleotides Nucleic Acids. 2006;25(1):61-72. PubMed PMID: 16440986.9: Lee CH, Daanen JF, Jiang M, Yu H, Kohlhaas KL, Alexander K, Jarvis MF, Kowaluk EL, Bhagwat SS. Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2419-22. PubMed PMID: 11549437.10: Bacchelli C, Condom R, Patino N, Aubertin AM. Synthesis and biological activities of new carbaacyclonucleosides and 1'-oxaacyclonucleosides related to clitocine. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):567-84. PubMed PMID: 10843493.1

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