34148-01-1|Clidanac|6-Chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid|-范德生物科技公司

Clidanac

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names：
6-Chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid
CAS号：
34148-01-1
MDL Number：
MF(分子式)： C16H19ClO2 MW(分子量)： 278.776
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Clidanac
英文别名	Clidanac; Britai; Clidanaco; TAI-284; TAI 284; TAI284; dl-TAI 284; Indanal.
CAS号	34148-01-1
SMILES	O=C(C1CCC2=C1C=C(Cl)C(C3CCCCC3)=C2)O
Inchi	InChI=1S/C16H19ClO2/c17-15-9-13-11(6-7-12(13)16(18)19)8-14(15)10-4-2-1-3-5-10/h8-10,12H,1-7H2,(H,18,19)
InchiKey	OIRAEJWYWSAQNG-UHFFFAOYSA-N
分子式 Formula	C16H19ClO2
分子量 Molecular Weight	278.776
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Clidanac(CAS:34148-01-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Clidanac, also known as TAI-284, is a potent anti-inflammatory drug. Clidanac was found to uncouple the oxidative phosphorylation and no difference was detected in the uncoupling potency of the two enantiomorphs.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kawai K, Shiojiri H, Fukushima H, Nozawa Y, Hasegawa J, Nozaki M, Tsurumi K, Fujimura H. The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers. Res Commun Chem Pathol Pharmacol. 1984 Sep;45(3):399-406. PubMed PMID: 6334337.

[2]Boettcher I, Elger W, Kirsch G, Siegmund F, Wachtel H. Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid. J Med Chem. 1984 Mar;27(3):413-4. PubMed PMID: 6608000.

[3] Hasegawa J, Nozaki M, Fujimura H. [The effects of various drugs on the binding site of bilirubin in serum albumin]. Nihon Yakurigaku Zasshi. 1984 Jan;83(1):79-83. Japanese. PubMed PMID: 6714852.

[4] Hutt AJ, Caldwell J. The metabolic chiral inversion of 2-arylpropionic acids--a novel route with pharmacological consequences. J Pharm Pharmacol. 1983 Nov;35(11):693-704. Review. PubMed PMID: 6139449.

[5] Imai H, Niwa M, Nozaki M, Tsurumi K, Fujimura H. [Influence of indomethacin and clidanac on the blood pressure lowering effect of beta-blockers]. Nihon Yakurigaku Zasshi. 1983 Jan;81(1):13-20. Japanese. PubMed PMID: 6133820.

6: Tamura S, Kuzuna S, Kawai K, Kishimoto S. Optical isomerization of R(-)-clidanac to the biologically active S(+)-isomer in guinea-pigs. J Pharm Pharmacol. 1981 Nov;33(11):701-6. PubMed PMID: 6118407.7: Tamura S, Kuzuna S, Kawai K. Inhibition of prostaglandin biosynthesis by clidanac and related compounds: structural and conformational requirements for PG synthetase inhibition. J Pharm Pharmacol. 1981 Jan;33(1):29-32. PubMed PMID: 6114148.8: Rosazza JP, Smith RV. Microbial models for drug metabolism. Adv Appl Microbiol. 1979;2

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