87501-14-2|Clerocidin|1-Naphthalenecarboxaldehyde, 5,5'-((tetrahydro-3'a,7'a-dihydroxydispiro(oxirane-2,3'(2'H)-difuro(2,3-b2',3'-e)(1,4)dioxin-7'(6'H),2''-oxirane)-2',6'-diyl)bis(methylene))bis(3,4,4a,5,6,7,8,8a-octahydro-5,6,8a-trimethyl-|-范德生物科技公司

Clerocidin

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names：
1-Naphthalenecarboxaldehyde, 5,5'-((tetrahydro-3'a,7'a-dihydroxydispiro(oxirane-2,3'(2'H)-difuro(2,3-b2',3'-e)(1,4)dioxin-7'(6'H),2''-oxirane)-2',6'-diyl)bis(methylene))bis(3,4,4a,5,6,7,8,8a-octahydro-5,6,8a-trimethyl-
CAS号：
87501-14-2
MDL Number：
MF(分子式)： C40H56O10 MW(分子量)： 696.878
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Clerocidin
英文别名	Clerocidin; Antibiotic PR-1350; PR-1350
CAS号	87501-14-2
Inchi	InChI=1S/C40H56O10/c1-23-13-15-33(3)25(19-41)9-7-11-27(33)35(23,5)17-29-37(21-45-37)39(43)31(47-29)49-40(44)32(50-39)48-30(38(40)22-46-38)18-36(6)24(2)14-16-34(4)26(20-42)10-8-12-28(34)36/h9-10,19-20,23-24,27-32,43-44H,7-8,11-18,21-22H2,1-6H3
InchiKey	LKJYEAJRWPUOGW-UHFFFAOYSA-N
分子式 Formula	C40H56O10
分子量 Molecular Weight	696.878
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Clerocidin(CAS:87501-14-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Clerocidin is a terpenoid antibiotic that inhibits bacterial DNA gyrase.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nadai M, Sattin G, Palù G, Palumbo M, Richter SN. Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conformations and detects tetraplex folding in a duplex environment. Biochim Biophys Acta. 2013 Oct;1830(10):4660-8. doi: 10.1016/j.bbagen.2013.05.039. Epub 2013 Jun 6. PubMed PMID: 23747297.

[2]Gatto B, Richter S, Moro S, Capranico G, Palumbo M. The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage. Nucleic Acids Res. 2001 Oct 15;29(20):4224-30. PubMed PMID: 11600711; PubMed Central PMCID: PMC60217.

[3] Binaschi M, Zagotto G, Palumbo M, Zunino F, Farinosi R, Capranico G. Irreversible and reversible topoisomerase II DNA cleavage stimulated by clerocidin: sequence specificity and structural drug determinants. Cancer Res. 1997 May 1;57(9):1710-6. PubMed PMID: 9135013.

[4] Richter SN, Menegazzo I, Nadai M, Moro S, Palumbo M. Reactivity of clerocidin towards adenine: implications for base-modulated DNA damage. Org Biomol Chem. 2009 Mar 7;7(5):976-85. doi: 10.1039/b819049f. Epub 2009 Jan 23. PubMed PMID: 19225681.

[5] Kawada S, Yamashita Y, Fujii N, Nakano H. Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin. Cancer Res. 1991 Jun 1;51(11):2922-5. PubMed PMID: 1851667.

6: Richter SN, Fabris D, Moro S, Palumbo M. Dissecting reactivity of clerocidin toward common buffer systems by means of selected drug analogues. Chem Res Toxicol. 2005 Jan;18(1):35-40. PubMed PMID: 15651847.7: Sehested M, Jensen PB. Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle. Biochem Pharmacol. 1996 Apr 12;51(7):879-86. PubMed PMID: 8651936.8: Nadai M, Palù G, Palumbo M, Richter SN. Differential targeting of unpaired bases within duplex DNA by the natural compound clerocidin: a valuable tool to dissect DNA secondary structure. PLoS One. 2012;7(12):e52994. doi: 10.1371/journal.pone.0052994. Epub 2012 Dec 28. PubMed PMID: 23285245; PubMed Central PMCID: PMC3532440.9: Pan XS, Dias M, Palumbo M, Fisher LM. Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage. Nucleic Acids Res. 2008 Oct;36(17):5516-29. doi: 10.1093/nar/gkn539. Epub 2008 Aug 22. PubMed PMID: 18723572; PubMed Central PMCID: PMC2553588.10: Richter S, Gatto B, Fabris D, Takao K, Kobayashi S, Palumbo M. Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action. Nucleic Acids Res. 2003 Sep 1;31(17):5149-56. PubMed PMID: 12930966; PubMed Central PMCID: PMC212796.1

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